TY - JOUR
T1 - Targeting ferroptosis as a vulnerability in cancer
AU - Lei, Guang
AU - Zhuang, Li
AU - Gan, Boyi
N1 - Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2022/7
Y1 - 2022/7
N2 - Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered enormous interest in cancer research communities, partly because it is a unique cell death modality that is mechanistically and morphologically different from other forms of cell death, such as apoptosis, and therefore holds great potential for cancer therapy. In this Review, we summarize the current understanding of ferroptosis-inducing and ferroptosis defence mechanisms, dissect the roles and mechanisms of ferroptosis in tumour suppression and tumour immunity, conceptualize the diverse vulnerabilities of cancer cells to ferroptosis, and explore therapeutic strategies for targeting ferroptosis in cancer.
AB - Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered enormous interest in cancer research communities, partly because it is a unique cell death modality that is mechanistically and morphologically different from other forms of cell death, such as apoptosis, and therefore holds great potential for cancer therapy. In this Review, we summarize the current understanding of ferroptosis-inducing and ferroptosis defence mechanisms, dissect the roles and mechanisms of ferroptosis in tumour suppression and tumour immunity, conceptualize the diverse vulnerabilities of cancer cells to ferroptosis, and explore therapeutic strategies for targeting ferroptosis in cancer.
UR - http://www.scopus.com/inward/record.url?scp=85127262854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85127262854&partnerID=8YFLogxK
U2 - 10.1038/s41568-022-00459-0
DO - 10.1038/s41568-022-00459-0
M3 - Review article
C2 - 35338310
AN - SCOPUS:85127262854
SN - 1474-175X
VL - 22
SP - 381
EP - 396
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 7
ER -