TY - JOUR
T1 - Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer
AU - Yadav, Vivek R.
AU - Prasad, Sahdeo
AU - Sung, Bokyung
AU - Kannappan, Ramaswamy
AU - Aggarwal, Bharat B.
PY - 2010/10
Y1 - 2010/10
N2 - Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer. In this review, we examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways linked to tumorigenesis. These triterpenes include avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide. This review thus supports the famous adage of Hippocrates, "Let food be thy medicine and medicine be thy food".
AB - Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer. In this review, we examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways linked to tumorigenesis. These triterpenes include avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide. This review thus supports the famous adage of Hippocrates, "Let food be thy medicine and medicine be thy food".
KW - Angiogenesis
KW - Apoptosis
KW - Inflammation
KW - Invasion
KW - Nuclear factor-κb
KW - Triterpenoids
KW - Tumor cell proliferation
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U2 - 10.3390/toxins2102428
DO - 10.3390/toxins2102428
M3 - Review article
C2 - 22069560
AN - SCOPUS:79952084572
SN - 2072-6651
VL - 2
SP - 2428
EP - 2466
JO - Toxins
JF - Toxins
IS - 10
ER -