Targeting metabolic transformation for cancer therapy

Daniel A. Tennant; Ral V. Durán; Eyal Gottlieb

doi:10.1038/nrc2817

Targeting metabolic transformation for cancer therapy

Daniel A. Tennant, Ral V. Durán, Eyal Gottlieb

Research output: Contribution to journal › Review article › peer-review

910 Scopus citations

Abstract

Cancer therapy has long relied on the rapid proliferation of tumour cells for effective treatment. However, the lack of specificity in this approach often leads to undesirable side effects. Many reports have described various 'metabolic transformation' events that enable cancer cells to survive, suggesting that metabolic pathways might be good targets. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered metabolic pathways of tumours. This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets.

Original language	English (US)
Pages (from-to)	267-277
Number of pages	11
Journal	Nature Reviews Cancer
Volume	10
Issue number	4
DOIs	https://doi.org/10.1038/nrc2817
State	Published - Apr 2010
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/nrc2817

Cite this

@article{62cb5caaab794ceead511344a941284e,

title = "Targeting metabolic transformation for cancer therapy",

abstract = "Cancer therapy has long relied on the rapid proliferation of tumour cells for effective treatment. However, the lack of specificity in this approach often leads to undesirable side effects. Many reports have described various 'metabolic transformation' events that enable cancer cells to survive, suggesting that metabolic pathways might be good targets. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered metabolic pathways of tumours. This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets.",

author = "Tennant, {Daniel A.} and Dur{\'a}n, {Ral V.} and Eyal Gottlieb",

year = "2010",

month = apr,

doi = "10.1038/nrc2817",

language = "English (US)",

volume = "10",

pages = "267--277",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Targeting metabolic transformation for cancer therapy

AU - Tennant, Daniel A.

AU - Durán, Ral V.

AU - Gottlieb, Eyal

PY - 2010/4

Y1 - 2010/4

N2 - Cancer therapy has long relied on the rapid proliferation of tumour cells for effective treatment. However, the lack of specificity in this approach often leads to undesirable side effects. Many reports have described various 'metabolic transformation' events that enable cancer cells to survive, suggesting that metabolic pathways might be good targets. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered metabolic pathways of tumours. This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets.

AB - Cancer therapy has long relied on the rapid proliferation of tumour cells for effective treatment. However, the lack of specificity in this approach often leads to undesirable side effects. Many reports have described various 'metabolic transformation' events that enable cancer cells to survive, suggesting that metabolic pathways might be good targets. There are currently several drugs under development or in clinical trials that are based on specifically targeting the altered metabolic pathways of tumours. This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets.

UR - http://www.scopus.com/inward/record.url?scp=77949967131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949967131&partnerID=8YFLogxK

U2 - 10.1038/nrc2817

DO - 10.1038/nrc2817

M3 - Review article

C2 - 20300106

AN - SCOPUS:77949967131

SN - 1474-175X

VL - 10

SP - 267

EP - 277

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 4

ER -

Targeting metabolic transformation for cancer therapy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this