@article{e44eaf04308f4776b8915c19962dc4f7,
title = "Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association",
abstract = "The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that increases this activity. These studies demonstrate how dysregulating AID phosphorylation can promote oncogenesis.",
keywords = "AICDA, B cells, MYC, activation-induced cytidine deaminase, chromosome translocation, class switch recombination, lithium, lymphoma, mutation",
author = "Yunxiang Mu and McBride, {Kevin M.}",
note = "Funding Information: This work was supported by the Welch Foundation (G-1847) UTMDACC Center for Cancer Epigenetics UTMDACC Center for Environmental and Molecular Carcinogenesis Three Strohm Sisters Family Foundation HHS | NIH | National Cancer Institute (NCI) (CA100632). Funding Information: This work was supported by the Welch Foundation (G-1847) UTMDACC Center for Cancer Epigenetics UTMDACC Center for Environmental and Molecular Carcinogenesis Three Strohm Sisters Family Foundation HHS j NIH j National Cancer Institute (NCI) (CA100632). Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Yunxiang Mu and Kevin M. McBride.",
year = "2018",
month = sep,
day = "3",
doi = "10.1080/23723556.2018.1432259",
language = "English (US)",
volume = "5",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "5",
}