Abstract
Myeloid-derived suppressor cells (MDSCs) are a unique subset of immune cells that promote an immunosuppressive phenotype due to their impacts on CD8 and regulatory T cell function. The inhibition of MDSC trafficking to the tumor microenvironment (TME) may represent a novel target in microsatellite stable (MSS) colorectal cancer with the potential to reprogram the immune system. Here, we review the rationale of inhibiting myeloid suppressor cell trafficking in treatment-refractory MSS colorectal cancer and circulating tumor DNA (ctDNA) positive settings to determine whether this approach can serve as a backbone for promoting immunotherapy response in this difficult-to-treat disease.
Original language | English (US) |
---|---|
Article number | 5484 |
Journal | Cancers |
Volume | 15 |
Issue number | 22 |
DOIs | |
State | Published - Nov 2023 |
Keywords
- immunotherapy
- microsatellite stable colorectal cancer
- minimal residual disease
- myeloid-derived suppressor cells
- tumor microenvironment
ASJC Scopus subject areas
- Oncology
- Cancer Research