TY - JOUR
T1 - Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer
T2 - How to aim?
AU - Xu, Min
AU - Zuo, Xiangsheng
AU - Shureiqi, Imad
N1 - Funding Information:
This work was supported in part by National Cancer Institute R01 grants CA142969 and 137213 ; and by the Duncan Family Institute Seed Funding Research Program .
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Peroxisome proliferator-activated receptor-β/δ (PPARδ) is a ubiquitously expressed, ligand-activated transcriptional factor that performs diverse critical functions in normal cells (e.g., fatty acid metabolism, obesity, apoptosis, and inflammation). Various studies in humans have found that PPARδ is upregulated in primary colorectal cancers; however, these findings have been challenged by those of other reports. Similarly, various in vitro and in vivo mechanistic pre-clinical models have yielded data demonstrating that PPARδ promotes colonic tumorigenesis, but other models have yielded data that contradicts this notion. Definitive studies are therefore needed to establish the exact role of PPARδ in human colorectal tumorigenesis and to provide a theoretical basis for PPARδ therapeutic targeting.
AB - Peroxisome proliferator-activated receptor-β/δ (PPARδ) is a ubiquitously expressed, ligand-activated transcriptional factor that performs diverse critical functions in normal cells (e.g., fatty acid metabolism, obesity, apoptosis, and inflammation). Various studies in humans have found that PPARδ is upregulated in primary colorectal cancers; however, these findings have been challenged by those of other reports. Similarly, various in vitro and in vivo mechanistic pre-clinical models have yielded data demonstrating that PPARδ promotes colonic tumorigenesis, but other models have yielded data that contradicts this notion. Definitive studies are therefore needed to establish the exact role of PPARδ in human colorectal tumorigenesis and to provide a theoretical basis for PPARδ therapeutic targeting.
KW - Colonic tumorigenesis
KW - Peroxisome proliferator-activated receptor-delta
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U2 - 10.1016/j.bcp.2012.09.031
DO - 10.1016/j.bcp.2012.09.031
M3 - Review article
C2 - 23041232
AN - SCOPUS:84873405702
SN - 0006-2952
VL - 85
SP - 607
EP - 611
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 5
ER -