TY - JOUR
T1 - Targeting potential drivers of COVID-19
T2 - Neutrophil extracellular traps
AU - Barnes, Betsy J.
AU - Adrover, Jose M.
AU - Baxter-Stoltzfus, Amelia
AU - Borczuk, Alain
AU - Cools-Lartigue, Jonathan
AU - Crawford, James M.
AU - Daßler-Plenker, Juliane
AU - Guerci, Philippe
AU - Huynh, Caroline
AU - Knight, Jason S.
AU - Loda, Massimo
AU - Looney, Mark R.
AU - McAllister, Florencia
AU - Rayes, Roni
AU - Renaud, Stephane
AU - Rousseau, Simon
AU - Salvatore, Steven
AU - Schwartz, Robert E.
AU - Spicer, Jonathan D.
AU - Yost, Christian C.
AU - Weber, Andrew
AU - Zuo, Yu
AU - Egeblad, Mikala
N1 - Publisher Copyright:
© 2020 Barnes et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10–15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils—the ability to form neutrophil extracellular traps (NETs)—may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.
AB - Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10–15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils—the ability to form neutrophil extracellular traps (NETs)—may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.
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U2 - 10.1084/jem.20200652
DO - 10.1084/jem.20200652
M3 - Review article
C2 - 32302401
AN - SCOPUS:85084041328
SN - 0022-1007
VL - 217
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 6
M1 - e20200652
ER -