TY - JOUR
T1 - Targeting transcription factors in cancer
T2 - Challenges and evolving strategies
AU - Redell, Michele S.
AU - Tweardy, David J.
PY - 2006/9
Y1 - 2006/9
N2 - As investigators uncover the molecular pathways leading to cancer, an abundance of potential molecular targets is accumulating. Among these targets, transcription factors are especially promising. This review discusses the reasons for focusing targeting efforts on transcription factors and highlights some salient examples. The advantages and problems with current methods for targeting are summarized. Finally, we discuss the drug delivery technologies in development that may one day make transcription factor targeting a therapeutic reality.
AB - As investigators uncover the molecular pathways leading to cancer, an abundance of potential molecular targets is accumulating. Among these targets, transcription factors are especially promising. This review discusses the reasons for focusing targeting efforts on transcription factors and highlights some salient examples. The advantages and problems with current methods for targeting are summarized. Finally, we discuss the drug delivery technologies in development that may one day make transcription factor targeting a therapeutic reality.
UR - http://www.scopus.com/inward/record.url?scp=33751003260&partnerID=8YFLogxK
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U2 - 10.1016/j.ddtec.2006.09.010
DO - 10.1016/j.ddtec.2006.09.010
M3 - Review article
C2 - 24980527
AN - SCOPUS:33751003260
SN - 1740-6749
VL - 3
SP - 261
EP - 267
JO - Drug Discovery Today: Technologies
JF - Drug Discovery Today: Technologies
IS - 3
ER -