Targeting XBP-1 as a novel anti-cancer strategy

Albert C. Koong; Vibha Chauhan; Lorenzo Romero-Ramirez

doi:10.4161/cbt.5.7.2973

Targeting XBP-1 as a novel anti-cancer strategy

Albert C. Koong, Vibha Chauhan, Lorenzo Romero-Ramirez

Image Guided Cancer Therapy Research Program

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Abstract

The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

Original language	English (US)
Pages (from-to)	756-759
Number of pages	4
Journal	Cancer Biology and Therapy
Volume	5
Issue number	7
DOIs	https://doi.org/10.4161/cbt.5.7.2973
State	Published - Jan 1 2006

Keywords

Hypoxia
IRE1
Tumor microenvironment
Unfolded protein response
XBP-1

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.4161/cbt.5.7.2973

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title = "Targeting XBP-1 as a novel anti-cancer strategy",

abstract = "The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.",

keywords = "Hypoxia, IRE1, Tumor microenvironment, Unfolded protein response, XBP-1",

author = "Koong, {Albert C.} and Vibha Chauhan and Lorenzo Romero-Ramirez",

note = "Funding Information: We would like to thank the members of the Koong lab who have contributed to some of the unpublished work described in this review. We would also like to acknowledge Amato Giaccia for his insightful comments on this manuscript. This work was supported by NCI grant CA112108 to A.C.K.",

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T1 - Targeting XBP-1 as a novel anti-cancer strategy

AU - Koong, Albert C.

AU - Chauhan, Vibha

AU - Romero-Ramirez, Lorenzo

N1 - Funding Information: We would like to thank the members of the Koong lab who have contributed to some of the unpublished work described in this review. We would also like to acknowledge Amato Giaccia for his insightful comments on this manuscript. This work was supported by NCI grant CA112108 to A.C.K.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

AB - The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

KW - Hypoxia

KW - IRE1

KW - Tumor microenvironment

KW - Unfolded protein response

KW - XBP-1

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Targeting XBP-1 as a novel anti-cancer strategy

Abstract

Keywords

ASJC Scopus subject areas

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