Abstract
T-prolymphocytic leukemia (T-PLL) is a rare mature T-cell neoplasm characterized by proliferation of prolymphocytes. Most cases involve the T-cell leukemia-1 (TCL1) gene at 14q11.2 resulting in overexpression of TCL-1, which is helpful for distinguishing T-PLL from other T-cell neoplasms. We report a patient with T-PLL whose leukemic cells were positive for TCL-1 by immunohistochemistry but with a normal karyotype. The patient had anti-CD52 antibody therapy for 12 weeks. In a follow-up bone marrow biopsy specimen, numerous TCL-1–positive cells were present, which raised the differential diagnosis of residual T-PLL. However, further immunophenotypic studies confirmed that these cells were hematogones. Therefore a diagnosis of recovering bone marrow was established. The patient underwent stem cell transplant and is now in complete remission. This case demonstrates that hematogones can express TCL-1, and this knowledge is very important for the differential diagnosis in the follow-up marrow of T-PLL patients.
Original language | English (US) |
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Pages (from-to) | 175-179 |
Number of pages | 5 |
Journal | Human Pathology |
Volume | 65 |
DOIs | |
State | Published - Jul 2017 |
Keywords
- Bone marrow
- Flow cytometry
- Follow-up
- Hematogone
- Lymphocytosis
- T-prolymphocytic leukemia
- TCL-1
ASJC Scopus subject areas
- Pathology and Forensic Medicine