TY - JOUR
T1 - Tec kinases
T2 - Modulators of lymphocyte signaling and development
AU - Lewis, Carol M.
AU - Broussard, Christine
AU - Czar, Michael J.
AU - Schwartzberg, Pamela L.
N1 - Funding Information:
The authors would like to thank members of the Schwartzberg laboratory for helpful discussions. PL Schwartzberg is supported in part through funds from the Searle Scholar's Program. CM Lewis is a Howard Hughes/National Institutes of Health Scholar.
PY - 2001/6/1
Y1 - 2001/6/1
N2 - The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which are required for activation of PLC-γ and downstream pathways.
AB - The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which are required for activation of PLC-γ and downstream pathways.
UR - http://www.scopus.com/inward/record.url?scp=0035366249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035366249&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(00)00221-1
DO - 10.1016/S0952-7915(00)00221-1
M3 - Review article
C2 - 11406363
AN - SCOPUS:0035366249
SN - 0952-7915
VL - 13
SP - 317
EP - 325
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -