Technical Aspects of Radioembolization with 90Y Microspheres

Riad Salem; Robert J. Lewandowski; Kent T. Sato; Bassel Atassi; Robert K. Ryu; Saad Ibrahim; Albert A. Nemcek; Reed A. Omary; David C. Madoff; Ravi Murthy

doi:10.1053/j.tvir.2007.08.001

Technical Aspects of Radioembolization with ⁹⁰Y Microspheres

Riad Salem, Robert J. Lewandowski, Kent T. Sato, Bassel Atassi, Robert K. Ryu, Saad Ibrahim, Albert A. Nemcek, Reed A. Omary, David C. Madoff, Ravi Murthy

Interventional Radiology

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Embolotherapy with radioactive microspheres, radioembolization, is gaining clinical acceptance as a therapeutic option for patients with liver malignancies. Knowledge of the anatomic variants in the mesenteric system is critical to safely administer this therapy. The purpose of this review is to provide a thorough discussion and detailed presentation of the technical aspects of radioembolization specifically as it pertains to the implantation devices. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. In addition, the basic principles described in this manuscript apply to all liver-directed transarterial therapies, such as chemoembolization and/or drug-eluting microspheres.

Original language	English (US)
Pages (from-to)	12-29
Number of pages	18
Journal	Techniques in vascular and interventional radiology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1053/j.tvir.2007.08.001
State	Published - Mar 2007

Keywords

SIR-Spheres
TheraSphere
Yttrium-90
brachytherapy
embolization
liver cancer
radioembolization
radiotherapy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

Access to Document

10.1053/j.tvir.2007.08.001

Cite this

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title = "Technical Aspects of Radioembolization with 90Y Microspheres",

abstract = "Embolotherapy with radioactive microspheres, radioembolization, is gaining clinical acceptance as a therapeutic option for patients with liver malignancies. Knowledge of the anatomic variants in the mesenteric system is critical to safely administer this therapy. The purpose of this review is to provide a thorough discussion and detailed presentation of the technical aspects of radioembolization specifically as it pertains to the implantation devices. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. In addition, the basic principles described in this manuscript apply to all liver-directed transarterial therapies, such as chemoembolization and/or drug-eluting microspheres.",

keywords = "SIR-Spheres, TheraSphere, Yttrium-90, brachytherapy, embolization, liver cancer, radioembolization, radiotherapy",

author = "Riad Salem and Lewandowski, {Robert J.} and Sato, {Kent T.} and Bassel Atassi and Ryu, {Robert K.} and Saad Ibrahim and Nemcek, {Albert A.} and Omary, {Reed A.} and Madoff, {David C.} and Ravi Murthy",

note = "Funding Information: Disclosure of potential conflicts of interest: RS has received research grant support and is a consultant for MDS Nordion. RM has received research grant support from Sirtex Medical. None of the other authors have disclosed a potential conflict of interest. ",

year = "2007",

month = mar,

doi = "10.1053/j.tvir.2007.08.001",

language = "English (US)",

volume = "10",

pages = "12--29",

journal = "Techniques in vascular and interventional radiology",

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AU - Salem, Riad

AU - Lewandowski, Robert J.

AU - Sato, Kent T.

AU - Atassi, Bassel

AU - Ryu, Robert K.

AU - Ibrahim, Saad

AU - Nemcek, Albert A.

AU - Omary, Reed A.

AU - Madoff, David C.

AU - Murthy, Ravi

N1 - Funding Information: Disclosure of potential conflicts of interest: RS has received research grant support and is a consultant for MDS Nordion. RM has received research grant support from Sirtex Medical. None of the other authors have disclosed a potential conflict of interest.

PY - 2007/3

Y1 - 2007/3

N2 - Embolotherapy with radioactive microspheres, radioembolization, is gaining clinical acceptance as a therapeutic option for patients with liver malignancies. Knowledge of the anatomic variants in the mesenteric system is critical to safely administer this therapy. The purpose of this review is to provide a thorough discussion and detailed presentation of the technical aspects of radioembolization specifically as it pertains to the implantation devices. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. In addition, the basic principles described in this manuscript apply to all liver-directed transarterial therapies, such as chemoembolization and/or drug-eluting microspheres.

AB - Embolotherapy with radioactive microspheres, radioembolization, is gaining clinical acceptance as a therapeutic option for patients with liver malignancies. Knowledge of the anatomic variants in the mesenteric system is critical to safely administer this therapy. The purpose of this review is to provide a thorough discussion and detailed presentation of the technical aspects of radioembolization specifically as it pertains to the implantation devices. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. In addition, the basic principles described in this manuscript apply to all liver-directed transarterial therapies, such as chemoembolization and/or drug-eluting microspheres.

KW - SIR-Spheres

KW - TheraSphere

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KW - brachytherapy

KW - embolization

KW - liver cancer

KW - radioembolization

KW - radiotherapy

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