TY - JOUR
T1 - Telomerase activity in cancer
T2 - a magic bullet or a mirage?
AU - Soria, J. C.
AU - Vielh, P.
AU - el-Naggar, A. K.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 1998/3
Y1 - 1998/3
N2 - Telomerase is an important enzyme required for maintenance of chromosome ends (telomeres) during cell division. Since elevated activity of telomerase has been selectively demonstrated in a large number of human cancers, it has generated considerable excitement as a potential cancer marker, a prognostic factor, and a target of possible anticancer strategy. This article details diagnostic, prognostic, and therapeutic prospects linked to the measurement of telomerase activity and the growing complexity of its regulation and function.
AB - Telomerase is an important enzyme required for maintenance of chromosome ends (telomeres) during cell division. Since elevated activity of telomerase has been selectively demonstrated in a large number of human cancers, it has generated considerable excitement as a potential cancer marker, a prognostic factor, and a target of possible anticancer strategy. This article details diagnostic, prognostic, and therapeutic prospects linked to the measurement of telomerase activity and the growing complexity of its regulation and function.
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U2 - 10.1097/00125480-199803000-00002
DO - 10.1097/00125480-199803000-00002
M3 - Review article
C2 - 9868515
AN - SCOPUS:0032009536
SN - 1072-4109
VL - 5
SP - 86
EP - 94
JO - Advances in anatomic pathology
JF - Advances in anatomic pathology
IS - 2
ER -