TY - JOUR
T1 - Telomere length in peripheral blood leukocytes and lung cancer risk
T2 - A large case-control study in caucasians
AU - Sanchez-Espiridion, Beatriz
AU - Chen, Meng
AU - Chang, Joe Y.
AU - Lu, Charles
AU - Chang, David W.
AU - Roth, Jack A.
AU - Wu, Xifeng
AU - Gu, Jian
PY - 2014/1/5
Y1 - 2014/1/5
N2 - Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case-control study of lung cancer and performed stratified analyses according to the two major histologic subtypes [adenocarcinoma and squamous cell carcinoma (SCC)]. Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcinoma, with the highest risk associated with female sex, younger age (<60 years), and lighter smoking (<30 pack-years). In contrast, long telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype.
AB - Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case-control study of lung cancer and performed stratified analyses according to the two major histologic subtypes [adenocarcinoma and squamous cell carcinoma (SCC)]. Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcinoma, with the highest risk associated with female sex, younger age (<60 years), and lighter smoking (<30 pack-years). In contrast, long telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype.
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U2 - 10.1158/0008-5472.CAN-13-2968
DO - 10.1158/0008-5472.CAN-13-2968
M3 - Article
C2 - 24618342
AN - SCOPUS:84900020857
SN - 0008-5472
VL - 74
SP - 2476
EP - 2486
JO - Cancer Research
JF - Cancer Research
IS - 9
ER -