Tenth International Conference of the Society for Integrative Oncology Translational Science in Integrative Oncology: From Bedside to Bench to Best Practices

Lynda G. Balneaves, Richard T. Lee, Emma S. Tomlinson Guns, Suzanna M. Zick, Susan Bauer-wu, Heather Greenlee, Heather Greenlee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The Effect of Two Types of Self-Administered Acupressure Compared to Standard of Care on Depression and Anxiety in Fatigued Breast Cancer Survivors Background: There are nearly 3 million breast cancer survivors (BCS) in the United States. Mood disorders in BCS are common, with 38% of women having moderate to high anxiety, and 22% having moderate to high depression. Depression may interfere with survivors’ quality of life, decreased adherence to adjuvant therapy and be associated with lower rates of survival. Current treatments for mood disorders can be difficult to implement and/or have unacceptable side effects; thus, there is a need for new treatments in this area. Methods: We compared the effect of 6 weeks of 2 types of self-administered acupressure (stimulating [SA] and relaxing [RA]) versus standard of care (SC) in 32 women for depression, and in 57 women with anxiety who reported ≥8 at baseline on the Hospital Anxiety Depression Scale (HADS) depression or anxiety subscales, as appropriate, and who were from an ongoing randomized clinical trial on acupressure for persistent cancer-related fatigue in BCS. Analyses of variance (ANOVA) were performed on mean differences of changes (baseline to week 6) in anxiety and depression subscales by group. Results: There was a significant decrease in depression (P =.02 vs SA; P =.06 vs SC) but not in anxiety (P =.36 vs SA; P =.46 vs SC) in the RA group compared with either SA or SC. This represents a −47% mean decrease from baseline in depression in the RA group versus −16% in the SA group and 22% in the SC group, and on average a movement from being borderline abnormal on the HADS depression subscale at baseline (9.2 ± 0.98, 0-21 point scale) to normal (4.9 ± 2.7) at 6 weeks. Conclusion: In this preliminary analysis, self-administered RA engenders a greater antidepressive response as compared with either SA or SC in fatigued BCS. These findings should be interpreted with caution given our small sample size. More rigorous studies are recommended.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalIntegrative cancer therapies
Volume13
Issue number1
DOIs
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine

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