Testing guidelines for hereditary non-polyposis colorectal cancer

Asad Umar; John I. Risinger; Ernest T. Hawk; J. Carl Barrett

doi:10.1038/nrc1278

Testing guidelines for hereditary non-polyposis colorectal cancer

Asad Umar, John I. Risinger, Ernest T. Hawk, J. Carl Barrett

Research output: Contribution to journal › Review article › peer-review

153 Scopus citations

Abstract

Hereditary non-polyposis colorectal cancer is almost always associated with microsatellite instability, so what is the best way to identify the disorder at an early-stage, and what should the next step be in preventing the development of colorectal cancer? Different clinical and molecular diagnostic guidelines have recently been proposed in the context of recent scientific advances, but how are these criteria interpreted and modified across the world?

Original language	English (US)
Pages (from-to)	153-158
Number of pages	6
Journal	Nature Reviews Cancer
Volume	4
Issue number	2
DOIs	https://doi.org/10.1038/nrc1278
State	Published - Feb 2004
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc1278

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title = "Testing guidelines for hereditary non-polyposis colorectal cancer",

abstract = "Hereditary non-polyposis colorectal cancer is almost always associated with microsatellite instability, so what is the best way to identify the disorder at an early-stage, and what should the next step be in preventing the development of colorectal cancer? Different clinical and molecular diagnostic guidelines have recently been proposed in the context of recent scientific advances, but how are these criteria interpreted and modified across the world?",

author = "Asad Umar and Risinger, {John I.} and Hawk, {Ernest T.} and Barrett, {J. Carl}",

note = "Funding Information: We thank E. Fearon, B. Vogelstein, R. Ohlsson and G. Klein for reading the manuscript. This work was supported by grants from the National Institutes of Health. We apologize in advance for any errors of omission or commission.",

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AU - Hawk, Ernest T.

AU - Barrett, J. Carl

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PY - 2004/2

Y1 - 2004/2

N2 - Hereditary non-polyposis colorectal cancer is almost always associated with microsatellite instability, so what is the best way to identify the disorder at an early-stage, and what should the next step be in preventing the development of colorectal cancer? Different clinical and molecular diagnostic guidelines have recently been proposed in the context of recent scientific advances, but how are these criteria interpreted and modified across the world?

AB - Hereditary non-polyposis colorectal cancer is almost always associated with microsatellite instability, so what is the best way to identify the disorder at an early-stage, and what should the next step be in preventing the development of colorectal cancer? Different clinical and molecular diagnostic guidelines have recently been proposed in the context of recent scientific advances, but how are these criteria interpreted and modified across the world?

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Testing guidelines for hereditary non-polyposis colorectal cancer

Abstract

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