Tests for the fit of the linear-quadratic model to radiation isoeffect data

Susan L. Tucker

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The linear-quadratic (LQ) model for cell survival is frequently extended to describe multifraction isoeffect data via the formula: In(response) = -n(ad + βd2), where d is the dose per fraction and n is the number of fractions. However, estimates of the quantity " α β" derived from such data are meaningless unless the use of the model is justified. Two methods are proposed for testing the fit of the multifraction LQ model to isoeffect data. If the use of the model cannot be rejected, each method also provides a new technique for estimating a f . The two methods are applied to published data from spleen,10 kidney,3 and colon. 9.11. In each case, consistent results are obtained from the two methods concerning the quality of the fit.

Original languageEnglish (US)
Pages (from-to)1933-1939
Number of pages7
JournalInternational journal of radiation oncology, biology, physics
Volume10
Issue number10
DOIs
StatePublished - Oct 1984

Fingerprint

Linear Models
Radiation
radiation
spleen
kidneys
Cell Survival
Colon
estimating
Spleen
Kidney
dosage
estimates

Keywords

  • Dose fractionation
  • Isoeffect data
  • Linear-quadratic model

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Tests for the fit of the linear-quadratic model to radiation isoeffect data. / Tucker, Susan L.

In: International journal of radiation oncology, biology, physics, Vol. 10, No. 10, 10.1984, p. 1933-1939.

Research output: Contribution to journalArticle

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