TY - JOUR
T1 - Tests for the fit of the linear-quadratic model to radiation isoeffect data
AU - Tucker, Susan L.
N1 - Funding Information:
Supported in part by Grants CA-29026, CA-06294 from the National Cancer institute, tutes of Health.
PY - 1984/10
Y1 - 1984/10
N2 - The linear-quadratic (LQ) model for cell survival is frequently extended to describe multifraction isoeffect data via the formula: In(response) = -n(ad + βd2), where d is the dose per fraction and n is the number of fractions. However, estimates of the quantity " α β" derived from such data are meaningless unless the use of the model is justified. Two methods are proposed for testing the fit of the multifraction LQ model to isoeffect data. If the use of the model cannot be rejected, each method also provides a new technique for estimating a f . The two methods are applied to published data from spleen,10 kidney,3 and colon. 9.11. In each case, consistent results are obtained from the two methods concerning the quality of the fit.
AB - The linear-quadratic (LQ) model for cell survival is frequently extended to describe multifraction isoeffect data via the formula: In(response) = -n(ad + βd2), where d is the dose per fraction and n is the number of fractions. However, estimates of the quantity " α β" derived from such data are meaningless unless the use of the model is justified. Two methods are proposed for testing the fit of the multifraction LQ model to isoeffect data. If the use of the model cannot be rejected, each method also provides a new technique for estimating a f . The two methods are applied to published data from spleen,10 kidney,3 and colon. 9.11. In each case, consistent results are obtained from the two methods concerning the quality of the fit.
KW - Dose fractionation
KW - Isoeffect data
KW - Linear-quadratic model
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U2 - 10.1016/0360-3016(84)90274-8
DO - 10.1016/0360-3016(84)90274-8
M3 - Article
C2 - 6490423
AN - SCOPUS:0021686098
SN - 0360-3016
VL - 10
SP - 1933
EP - 1939
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 10
ER -