TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis

Delphine Javelaud; Vasileia I. Alexaki; Sylviane Dennler; Khalid S. Mohammad; Theresa A. Guise; Alain Mauviel

doi:10.1158/0008-5472.CAN-11-1194

TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis

Delphine Javelaud, Vasileia I. Alexaki, Sylviane Dennler, Khalid S. Mohammad, Theresa A. Guise, Alain Mauviel

Research output: Contribution to journal › Short survey › peer-review

157 Scopus citations

Abstract

The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.

Original language	English (US)
Pages (from-to)	5606-5610
Number of pages	5
Journal	Cancer Research
Volume	71
Issue number	17
DOIs	https://doi.org/10.1158/0008-5472.CAN-11-1194
State	Published - Sep 1 2011
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/0008-5472.CAN-11-1194

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title = "TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis",

abstract = "The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.",

author = "Delphine Javelaud and Alexaki, {Vasileia I.} and Sylviane Dennler and Mohammad, {Khalid S.} and Guise, {Theresa A.} and Alain Mauviel",

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AU - Javelaud, Delphine

AU - Alexaki, Vasileia I.

AU - Dennler, Sylviane

AU - Mohammad, Khalid S.

AU - Guise, Theresa A.

AU - Mauviel, Alain

PY - 2011/9/1

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N2 - The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.

AB - The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.

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JO - Cancer Research

JF - Cancer Research

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TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis

Abstract

ASJC Scopus subject areas

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