Abstract
Background: The baseline absolute monocyte count and absolute lymphocyte count were used to generate a prognostic index (the AMLPI) for survival in diffuse large B-cell lymphoma (DLBCL). Methods: Data from 245 patients with DLBCL who were treated with standard R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, prednisone) were reviewed. By using the values previously reported for the AMLPI, its prognostic value was examined in our population. Results: After a median follow-up of 22 months for censored observations, the 3-year progression-free survival (PFS) rates for the international prognostic index (IPI) 0-2 and 3-5 risk groups were 73% and 58%, respectively (P =.0004); comparable overall survival (OS) rates were 88% and 68%, respectively (P <.0001). For patients with IPI scores of 0-2, 1-year PFS rates for AMLPI low-, intermediate-, and high-risk groups were 92%, 89%, and 80%, respectively (P =.022); comparable 1-year OS rates were 96%, 95%, and 80%, respectively (P =.049). By multivariate analysis, with the adjustment of IPI in the model, AMLPI effects (low- vs. high-risk groups) on PFS and OS rates were significant, with P =.046 (hazard ratio [HR] 0.402 [95% CI, 0.164-0.986] and P =.052 (HR 0.325 [95% CI, 0.104-1.011]), respectively. Conclusions: The absolute monocyte and lymphocyte counts prognostic index (the AMLPI) may add prognostic value beyond that of the IPI for patients with DLBCL who receive R-CHOP.
Original language | English (US) |
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Pages (from-to) | 15-18 |
Number of pages | 4 |
Journal | Clinical Lymphoma, Myeloma and Leukemia |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2013 |
Keywords
- International prognostic factors index
- Large cell lymphoma
- Prognostic factors
- R-CHOP chemotherapy
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
MD Anderson CCSG core facilities
- Biostatistics Resource Group
- Clinical and Translational Research Center