The antibody response to Epstein-Barr virions is altered in multiple sclerosis

J. W. Lindsey; U. Khan; W. Ansari; T. Powell; Y. H. Wang; M. S. Guirguis

doi:10.1016/j.jneuroim.2012.09.007

The antibody response to Epstein-Barr virions is altered in multiple sclerosis

J. W. Lindsey, U. Khan, W. Ansari, T. Powell, Y. H. Wang, M. S. Guirguis

Breast Imaging

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10 Scopus citations

Abstract

Infection with Epstein-Barr virus (EBV) is associated with multiple sclerosis (MS), and patients with MS have an increased antibody response to some EBV antigens. The major antigens of EBV are only partly defined. Our hypothesis is that the antibody response to EBV is altered in MS. With ELISA, we found that antibodies to EB virions were increased in both serum and CSF of MS patients. Western blots demonstrated that there are multiple different antigens recognized. The antibody response was generally higher in MS to all EBV antigens, with particularly significant increases for certain antigens. We conclude that the antibody response to EBV in MS is generally increased with altered specificity.

Original language	English (US)
Pages (from-to)	146-153
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	254
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.09.007
State	Published - Jan 15 2013

Keywords

Antibody response
Epstein-Barr virus
Immunoglobulin G
Multiple sclerosis
Western blot

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2012.09.007

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title = "The antibody response to Epstein-Barr virions is altered in multiple sclerosis",

abstract = "Infection with Epstein-Barr virus (EBV) is associated with multiple sclerosis (MS), and patients with MS have an increased antibody response to some EBV antigens. The major antigens of EBV are only partly defined. Our hypothesis is that the antibody response to EBV is altered in MS. With ELISA, we found that antibodies to EB virions were increased in both serum and CSF of MS patients. Western blots demonstrated that there are multiple different antigens recognized. The antibody response was generally higher in MS to all EBV antigens, with particularly significant increases for certain antigens. We conclude that the antibody response to EBV in MS is generally increased with altered specificity.",

keywords = "Antibody response, Epstein-Barr virus, Immunoglobulin G, Multiple sclerosis, Western blot",

author = "Lindsey, {J. W.} and U. Khan and W. Ansari and T. Powell and Wang, {Y. H.} and Guirguis, {M. S.}",

note = "Funding Information: This work was supported in part by the Clayton Foundation for Research . T.P. and M.G. were recipients of student summer research scholarships from the Foundation of the Consortium of Multiple Sclerosis Centers . Some of the CSF specimens were obtained from the Human Brain and Spinal Fluid Resource Center, VA West Los Angeles Healthcare Center, which is sponsored by NINDS/NIMH , the National Multiple Sclerosis Society , and the Department of Veterans Affairs .",

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T1 - The antibody response to Epstein-Barr virions is altered in multiple sclerosis

AU - Lindsey, J. W.

AU - Khan, U.

AU - Ansari, W.

AU - Powell, T.

AU - Wang, Y. H.

AU - Guirguis, M. S.

N1 - Funding Information: This work was supported in part by the Clayton Foundation for Research . T.P. and M.G. were recipients of student summer research scholarships from the Foundation of the Consortium of Multiple Sclerosis Centers . Some of the CSF specimens were obtained from the Human Brain and Spinal Fluid Resource Center, VA West Los Angeles Healthcare Center, which is sponsored by NINDS/NIMH , the National Multiple Sclerosis Society , and the Department of Veterans Affairs .

PY - 2013/1/15

Y1 - 2013/1/15

N2 - Infection with Epstein-Barr virus (EBV) is associated with multiple sclerosis (MS), and patients with MS have an increased antibody response to some EBV antigens. The major antigens of EBV are only partly defined. Our hypothesis is that the antibody response to EBV is altered in MS. With ELISA, we found that antibodies to EB virions were increased in both serum and CSF of MS patients. Western blots demonstrated that there are multiple different antigens recognized. The antibody response was generally higher in MS to all EBV antigens, with particularly significant increases for certain antigens. We conclude that the antibody response to EBV in MS is generally increased with altered specificity.

AB - Infection with Epstein-Barr virus (EBV) is associated with multiple sclerosis (MS), and patients with MS have an increased antibody response to some EBV antigens. The major antigens of EBV are only partly defined. Our hypothesis is that the antibody response to EBV is altered in MS. With ELISA, we found that antibodies to EB virions were increased in both serum and CSF of MS patients. Western blots demonstrated that there are multiple different antigens recognized. The antibody response was generally higher in MS to all EBV antigens, with particularly significant increases for certain antigens. We conclude that the antibody response to EBV in MS is generally increased with altered specificity.

KW - Antibody response

KW - Epstein-Barr virus

KW - Immunoglobulin G

KW - Multiple sclerosis

KW - Western blot

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The antibody response to Epstein-Barr virions is altered in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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