Abstract
Objective: To investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer. Methods: Using polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) and the primer-introduced restriction analysis (PIRA)-PCR assay to genotype the CDT1 838G/A and GMNN 387C/A polymorphisms in a case-control study of 427 breast cancer cases and 477 cancer-free controls in a Chinese population. Results: No significant association of the CDT1 838G/A and GMNN 387C/A polymorphisms with the risk of breast cancer was found (adjusted OR: 1.16, 95% CI: 0.88-1.54 for CDT1 GA + AA genotypes and adjusted OR:0.90, 95% CI:0.67-1.21 for GMNN CA + AA genotypes). However, in the stratified analyses, a significant association of CDT1 GA + AA genotypes with breast cancer risk among subjects with family history of cancer was found (adjusted OR: 2.21, 95% CI: 1.20-4.09). Conclusion: These findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer, but CDT1 variant may have a potential role only in genetically susceptible women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 544-547 |
| Number of pages | 4 |
| Journal | Chinese Journal of Medical Genetics |
| Volume | 23 |
| Issue number | 5 |
| State | Published - Oct 10 2006 |
Keywords
- Breast cancer
- CDT1 gene
- GMNN gene
- Genetic polymorphism
ASJC Scopus subject areas
- Genetics(clinical)