TY - JOUR
T1 - The association of specific “favorable” cytogenetic abnormalities with secondary leukemia
AU - Kantarjian, Hagop M.
AU - Keating, Michael J.
AU - Walters, Ronald S.
AU - Beran, Miloslav
AU - McLaughlin, Peter
AU - McCredie, Kenneth B.
AU - Freireich, And Emil J.
PY - 1986/8/15
Y1 - 1986/8/15
N2 - Eight patients with secondary leukemia and specific cytogenetic abnormalities involving inversion of chromosome 16, or translations between chromosomes 15 and 17, or 8 and 21, are presented. Seven of them (87%) achieved complete remission with chemotherapy. The occurrence of these karyotypes, which is unusual in secondary leukemia, and the favorable response to chemotherapy are discussed in relation to the pathogenesis of the disease.
AB - Eight patients with secondary leukemia and specific cytogenetic abnormalities involving inversion of chromosome 16, or translations between chromosomes 15 and 17, or 8 and 21, are presented. Seven of them (87%) achieved complete remission with chemotherapy. The occurrence of these karyotypes, which is unusual in secondary leukemia, and the favorable response to chemotherapy are discussed in relation to the pathogenesis of the disease.
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U2 - 10.1002/1097-0142(19860815)58:4<924::AID-CNCR2820580420>3.0.CO;2-Y
DO - 10.1002/1097-0142(19860815)58:4<924::AID-CNCR2820580420>3.0.CO;2-Y
M3 - Article
C2 - 3719557
AN - SCOPUS:0022546003
SN - 0008-543X
VL - 58
SP - 924
EP - 927
JO - Cancer
JF - Cancer
IS - 4
ER -