Abstract
The in vitro and in vivo activities of catheters coated with minocycline and rifampin and with chlorhexidine gluconate and silver sulfadiazine were evaluated. When incubated in serum at 37°C, the half-life of the inhibitory activity of catheters coated with minocycline and rifampin was 25 days compared with 3 clays for catheters coated with chlorhexidine gluconate and silver sulfadiazine. In a rabbit model, catheters coated with minocycline and rifampin were significantly more efficacious than catheters coated with chlorhexidine and silver sulfadiazine in preventing colonization and infection with Staphylococcus aureus (P < .05). Catheters coated with minocycline and rifampin demonstrated broad-spectrum in vitro inhibitory activity against gram-positive bacteria, gram-negative bacteria, and Candida albicans that was significantly superior to the inhibitory activity of catheters coated with chlorhexidine gluconate and silver sulfadiazine (P < .01). Minocycline and rifampin were also highly efficacious in preventing colonization and infection in vivo.
Original language | English (US) |
---|---|
Pages (from-to) | 418-424 |
Number of pages | 7 |
Journal | Journal of Infectious Diseases |
Volume | 173 |
Issue number | 2 |
DOIs | |
State | Published - 1996 |
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases