TY - GEN
T1 - The cardiovascular microenvironment
AU - Reinhart-King, Cynthia A.
AU - Fujiwara, Keigi
AU - King, Michael R.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - Endothelial cell response to the complex hemodynamic environment of the circulatory system is critical to the pathophysiological regulation of the cardiovascular system; however the mechanism by which this mechanical signal is transduced remains poorly understood. Recent in vivo evidence suggests that cells are capable of responding locally to shear stress, on the length scale of a single cell. Because of the complexity of the in vivo environment, we have designed and characterized an in vitro microchannel chamber with well-defined rheological conditions. This system is being used to investigate endothelial cell signaling response to shear stress, thereby bridging the gap between in vivo and in vitro observations.
AB - Endothelial cell response to the complex hemodynamic environment of the circulatory system is critical to the pathophysiological regulation of the cardiovascular system; however the mechanism by which this mechanical signal is transduced remains poorly understood. Recent in vivo evidence suggests that cells are capable of responding locally to shear stress, on the length scale of a single cell. Because of the complexity of the in vivo environment, we have designed and characterized an in vitro microchannel chamber with well-defined rheological conditions. This system is being used to investigate endothelial cell signaling response to shear stress, thereby bridging the gap between in vivo and in vitro observations.
UR - http://www.scopus.com/inward/record.url?scp=37249087111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37249087111&partnerID=8YFLogxK
U2 - 10.1115/ICNMM2007-30167
DO - 10.1115/ICNMM2007-30167
M3 - Conference contribution
AN - SCOPUS:37249087111
SN - 079184272X
SN - 9780791842720
T3 - Proceedings of the 5th International Conference on Nanochannels, Microchannels and Minichannels, ICNMM2007
SP - 1077
EP - 1082
BT - Proceedings of the 5th International Conference on Nanochannels, Microchannels and Minichannels, ICNMM2007
T2 - 5th International Conference on Nanochannels, Microchannels and Minichannels, ICNMM2007
Y2 - 18 June 2007 through 20 June 2007
ER -