TY - JOUR
T1 - The clinical research on serum cystatin-C alteration on stage II chronic kidney disease with gubenquduyishen decoction treatment
AU - Dong, Feixia
AU - Cheng, Jinguo
AU - Lin, Songcang
AU - Hu, Zhen
AU - Chen, Gang
AU - He, Liqun
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China Grant ( 30873259 ); Shanghai Excellent academic leaders Project Grant (08XD14039); E-institute of TCM Internal Medicine of Shanghai Municipal Education Commission Grant ( E03008 ); Innovative Research Team in Universities, Shanghai Municipal Education Commission of Grant; State Administration of Traditional Chinese Medicine Key Subjects ( 30301041210 ); Wenzhou Science & Technology Bureau of Grant ( Y20070049 ); Wenzhou Municipal Health Bureau of Grant ( 2007201 ); and Zhejiang Province 151 and Wenzhou Municipal 551 Talented Grant.
PY - 2010/10
Y1 - 2010/10
N2 - Aim of the study: Gubenquduyishen (GBQDYS) decoction, the modified remedy of a classical Chinese prescription named Liuweidihuang decoction, has been clinically employed to treat nephrotic syndrome and chronic nephritis in chronic kidney disease (CKD). The present study was designed to examine whether GBQDYS decoction has a protective effect on renal function associated with the raised level of cystatin-C (Cys-C), serum creatinine (Scr), blood urea nitrogen (BUN) and decreased Glomerular filtration rate (GFR) in stage-II CKD. Materials and methods: A total of 68 stage-II CKD patients were randomly divided into two groups, the control group and the treatment group who received GBQDYS decoction as an additional therapy supplement. Results: Following up on a period of 48 months, levels of serum Cys-C, Scr, and BUN were significantly reduced by the treatment of GBQDYS decoction and GFR was elevated in the treated group. Whereas not achieved in the control group, suggesting the nephro-protective activity of GBQDYS decoction.Conclusions: Taken together, these results demonstrated that GBQDYS decoction is able to protect renal function by delaying the progression of renal failure, and this may be used as an effective alternative treatment for CKD patients.
AB - Aim of the study: Gubenquduyishen (GBQDYS) decoction, the modified remedy of a classical Chinese prescription named Liuweidihuang decoction, has been clinically employed to treat nephrotic syndrome and chronic nephritis in chronic kidney disease (CKD). The present study was designed to examine whether GBQDYS decoction has a protective effect on renal function associated with the raised level of cystatin-C (Cys-C), serum creatinine (Scr), blood urea nitrogen (BUN) and decreased Glomerular filtration rate (GFR) in stage-II CKD. Materials and methods: A total of 68 stage-II CKD patients were randomly divided into two groups, the control group and the treatment group who received GBQDYS decoction as an additional therapy supplement. Results: Following up on a period of 48 months, levels of serum Cys-C, Scr, and BUN were significantly reduced by the treatment of GBQDYS decoction and GFR was elevated in the treated group. Whereas not achieved in the control group, suggesting the nephro-protective activity of GBQDYS decoction.Conclusions: Taken together, these results demonstrated that GBQDYS decoction is able to protect renal function by delaying the progression of renal failure, and this may be used as an effective alternative treatment for CKD patients.
KW - Chinese herb
KW - Chronic kidney disease
KW - Cystatin-C
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U2 - 10.1016/j.jep.2010.07.032
DO - 10.1016/j.jep.2010.07.032
M3 - Article
C2 - 20659545
AN - SCOPUS:77956650119
SN - 0378-8741
VL - 131
SP - 581
EP - 584
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 3
ER -