The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

D. J. Straus; M. Andreeff; H. J. Hansen; R. Mertelsmann; B. Koziner; R. Chaganti; T. S. Gee; S. McKenzie; M. R. Melamed; B. D. Clarkson

doi:10.1182/blood.v54.6.1428.1428

The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

D. J. Straus, M. Andreeff, H. J. Hansen, R. Mertelsmann, B. Koziner, R. Chaganti, T. S. Gee, S. McKenzie, M. R. Melamed, B. D. Clarkson

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6 Scopus citations

Abstract

Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.

Original language	English (US)
Pages (from-to)	1428-1433
Number of pages	6
Journal	Blood
Volume	54
Issue number	6
DOIs	https://doi.org/10.1182/blood.v54.6.1428.1428
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v54.6.1428.1428

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Straus, D. J., Andreeff, M., Hansen, H. J., Mertelsmann, R., Koziner, B., Chaganti, R., Gee, T. S., McKenzie, S., Melamed, M. R., & Clarkson, B. D. (1979). The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis. Blood, 54(6), 1428-1433. https://doi.org/10.1182/blood.v54.6.1428.1428

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title = "The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis",

abstract = "Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.",

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doi = "10.1182/blood.v54.6.1428.1428",

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AU - Straus, D. J.

AU - Andreeff, M.

AU - Hansen, H. J.

AU - Mertelsmann, R.

AU - Koziner, B.

AU - Chaganti, R.

AU - Gee, T. S.

AU - McKenzie, S.

AU - Melamed, M. R.

AU - Clarkson, B. D.

PY - 1979

Y1 - 1979

N2 - Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.

AB - Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.

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The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

Abstract

ASJC Scopus subject areas

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