The correlations between IL-17 vs. Th17 cells and cancer patient survival: A systematic review

Simone Punt; Jessica M. Langenhoff; H. Putter; Gert Jan Fleuren; Arko Gorter; Ekaterina S. Jordanova

doi:10.4161/2162402X.2014.984547

The correlations between IL-17 vs. Th17 cells and cancer patient survival: A systematic review

Simone Punt, Jessica M. Langenhoff, H. Putter, Gert Jan Fleuren, Arko Gorter, Ekaterina S. Jordanova

Melanoma Medical Oncology

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17⁺ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17⁺ cells.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	OncoImmunology
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/2162402X.2014.984547
State	Published - 2015

Keywords

Cancer
IL-17
Survival
Th17
Tumor microenvironment

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/2162402X.2014.984547

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abstract = "Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.",

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AU - Punt, Simone

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AU - Fleuren, Gert Jan

AU - Gorter, Arko

AU - Jordanova, Ekaterina S.

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AB - Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.

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The correlations between IL-17 vs. Th17 cells and cancer patient survival: A systematic review

Abstract

Keywords

ASJC Scopus subject areas

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