Abstract
Recent studies indicate that increasing protein synthesis in cells beyond the capacity for folding of nascent polypeptides or accumulation of unfolded/misfolded proteins within the endoplasmic reticulum (ER) lumen will disrupt ER homeostasis and trigger the unfolded protein response (UPR). ER stress or UPR is not only critical for cell homeostasis and embryogenesis, but ERS/UPR can initiate inflammatory responses in specialized cells and tissues to participate in the pathogenesis of inflammatory diseases. Here, we summarize recent progresses in the roles of UPR and inflammation coupling in the pathogenesis of human chronic diseases, by which may result in approaches to manipulate ERS-UPR-inflammation and to provide therapeutic opportunity for the prevention and treatment of chronic diseases.
Original language | English (US) |
---|---|
Pages (from-to) | 261-266 |
Number of pages | 6 |
Journal | Sheng li ke xue jin zhan [Progress in physiology] |
Volume | 41 |
Issue number | 4 |
State | Published - Aug 2010 |
ASJC Scopus subject areas
- General Medicine