TY - JOUR
T1 - The developmental transcription factor slug is widely expressed in tissues of adult mice
AU - Parent, Allison E.
AU - Choi, Changsun
AU - Caudy, Kristin
AU - Gridley, Thomas
AU - Kusewitt, Donna F.
PY - 2004/7
Y1 - 2004/7
N2 - The Slug transcription factor plays an important role in epithelial-mesenchymal transformation during embryogenesis and is expressed in adult tissues during carcinogenesis. By detecting expression of a Slug-β-galactosidase fusion protein, we have now demonstrated that Slug is also re-expressed in a variety of normal tissues in the adult mouse. Slug is expressed at relatively high levels in patchy stretches of basal cells in stratified and pseudostratified epithelium, including skin, oral mucosa, esophagus, stomach, rectum, cervix, and trachea. Slug is also found at variable levels in fibroblasts and stromal smooth muscle cells in many tissues. Sites of more intense Slug expression in mesenchymal tissues include cartilage, kidney glomeruli, lung, ovary, and uterus. Therefore, Slug expression is not restricted to the period of embryonic development or to pathological processes. The pattern of localization to basal cells in various epithelia suggests that Slug may play a role in the cell migration that occurs during continual renewal of these tissues.
AB - The Slug transcription factor plays an important role in epithelial-mesenchymal transformation during embryogenesis and is expressed in adult tissues during carcinogenesis. By detecting expression of a Slug-β-galactosidase fusion protein, we have now demonstrated that Slug is also re-expressed in a variety of normal tissues in the adult mouse. Slug is expressed at relatively high levels in patchy stretches of basal cells in stratified and pseudostratified epithelium, including skin, oral mucosa, esophagus, stomach, rectum, cervix, and trachea. Slug is also found at variable levels in fibroblasts and stromal smooth muscle cells in many tissues. Sites of more intense Slug expression in mesenchymal tissues include cartilage, kidney glomeruli, lung, ovary, and uterus. Therefore, Slug expression is not restricted to the period of embryonic development or to pathological processes. The pattern of localization to basal cells in various epithelia suggests that Slug may play a role in the cell migration that occurs during continual renewal of these tissues.
KW - Gene expression
KW - Histocytochemistry
KW - Immunohistochemistry
KW - Mouse
KW - Slug protein
UR - http://www.scopus.com/inward/record.url?scp=3042703943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042703943&partnerID=8YFLogxK
U2 - 10.1369/jhc.4A6277.2004
DO - 10.1369/jhc.4A6277.2004
M3 - Article
C2 - 15208362
AN - SCOPUS:3042703943
SN - 0022-1554
VL - 52
SP - 959
EP - 965
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
IS - 7
ER -