TY - JOUR
T1 - The diagnostic value of apolipoprotein E in malignant pleural effusion associated with non-small cell lung cancer
AU - Wang, Yumin
AU - Chen, Zengqiang
AU - Chen, Jie
AU - Pan, Jingye
AU - Zhang, Wenhui
AU - Pan, Qinshi
AU - Ding, Hongyan
AU - Lin, Xiaomei
AU - Wen, Xiushu
AU - Li, Yangyang
AU - Meng, Qing H.
N1 - Funding Information:
This work was supported by the funds from Wenzhou Municipal Science and Technology Bureau, China ( Y20110041 ).
PY - 2013/6/5
Y1 - 2013/6/5
N2 - Background: Apolipoprotein E (apoE) levels have been shown to be elevated in pleural effusion of patients with non-small cell lung cancer (NSCLC). However, the diagnostic value of apoE in pleural effusion in NSCLC has not been well validated and established. Methods: Samples of malignant pleural effusions (MPE) and benign effusions were collected and analyzed for apoE, tumor markers, and other biochemical changes. Results: ApoE levels were significantly higher in MPE (n= 160) than in benign pleural effusions (n= 40). They were higher in adenocarcinoma-associated MPE than in squamous cell carcinoma- and large cell carcinoma-associated MPE. The receiver operating characteristic curve showed that the sensitivity and specificity of apoE for the diagnosis of MPE were 87.5% and 85.3%, respectively, at the cutoff 105. ng/ml, and the area under the curve (AUC) was 0.748. For the diagnosis of adenocarcinoma-associated MPE, apoE achieved sensitivity and specificity of 70.8% and 83.30%, respectively, and the AUC was the highest of all the markers. Conclusions: ApoE levels are significantly increased in the pleural effusion of patients with NSCLC. Increased concentration of apoE in a pleural effusion is a potential marker for the diagnosis of MPE as well as for differential diagnosis of MPE in NSCLC.
AB - Background: Apolipoprotein E (apoE) levels have been shown to be elevated in pleural effusion of patients with non-small cell lung cancer (NSCLC). However, the diagnostic value of apoE in pleural effusion in NSCLC has not been well validated and established. Methods: Samples of malignant pleural effusions (MPE) and benign effusions were collected and analyzed for apoE, tumor markers, and other biochemical changes. Results: ApoE levels were significantly higher in MPE (n= 160) than in benign pleural effusions (n= 40). They were higher in adenocarcinoma-associated MPE than in squamous cell carcinoma- and large cell carcinoma-associated MPE. The receiver operating characteristic curve showed that the sensitivity and specificity of apoE for the diagnosis of MPE were 87.5% and 85.3%, respectively, at the cutoff 105. ng/ml, and the area under the curve (AUC) was 0.748. For the diagnosis of adenocarcinoma-associated MPE, apoE achieved sensitivity and specificity of 70.8% and 83.30%, respectively, and the AUC was the highest of all the markers. Conclusions: ApoE levels are significantly increased in the pleural effusion of patients with NSCLC. Increased concentration of apoE in a pleural effusion is a potential marker for the diagnosis of MPE as well as for differential diagnosis of MPE in NSCLC.
KW - ApoE
KW - Malignant pleural effusion
KW - Non-small cell lung cancer
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U2 - 10.1016/j.cca.2013.03.013
DO - 10.1016/j.cca.2013.03.013
M3 - Article
C2 - 23523589
AN - SCOPUS:84876708281
SN - 0009-8981
VL - 421
SP - 230
EP - 235
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -