The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study

Paul D. Ling; John A. Lednicky; Wendy A. Keitel; David G. Poston; Zoe S. White; Rong Sheng Peng; Zhensheng Liu; Satish K. Mehta; Duane L. Pierson; Cliona M. Rooney; Regis A. Vilchez; E. O.Brian Smith; Janet S. Butel

doi:10.1086/374739

The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study

Paul D. Ling, John A. Lednicky, Wendy A. Keitel, David G. Poston, Zoe S. White, Rong Sheng Peng, Zhensheng Liu, Satish K. Mehta, Duane L. Pierson, Cliona M. Rooney, Regis A. Vilchez, E. O.Brian Smith, Janet S. Butel

Epidemiology

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Humans are infected with viruses that establish long-term persistent infections. To address whether immunocompetent individuals control virus reactivation globally or independently and to identify patterns of sporadic reactivation, we monitored herpesviruses and polyomaviruses in 30 adults, over 14 months. Epstein-Barr virus (EBV) DNA was quantitated in saliva and peripheral blood mononuclear cells (PBMCs), cytomegalovirus (CMV) was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs. All individuals shed EBV in saliva, whereas 67% had ≥1 blood sample positive for EBV. Levels of EBV varied widely. CMV shedding occurred infrequently but occurred more commonly in younger individuals (P < .03). JCV and BKV virurias were 46.7% and 0%, respectively. JCV shedding was age dependent and occurred commonly in individuals ≥40 years old (P < .03). Seasonal variation was observed in shedding of EBV and JCV, but there was no correlation among shedding of EBV, CMV, and JCV (P > .50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations.

Original language	English (US)
Pages (from-to)	1571-1580
Number of pages	10
Journal	Journal of Infectious Diseases
Volume	187
Issue number	10
DOIs	https://doi.org/10.1086/374739
State	Published - May 15 2003

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/374739

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Ling, P. D., Lednicky, J. A., Keitel, W. A., Poston, D. G., White, Z. S., Peng, R. S., Liu, Z., Mehta, S. K., Pierson, D. L., Rooney, C. M., Vilchez, R. A., Smith, E. O. B., & Butel, J. S. (2003). The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study. Journal of Infectious Diseases, 187(10), 1571-1580. https://doi.org/10.1086/374739

Ling, PD, Lednicky, JA, Keitel, WA, Poston, DG, White, ZS, Peng, RS, Liu, Z, Mehta, SK, Pierson, DL, Rooney, CM, Vilchez, RA, Smith, EOB & Butel, JS 2003, 'The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study', Journal of Infectious Diseases, vol. 187, no. 10, pp. 1571-1580. https://doi.org/10.1086/374739

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title = "The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study",

abstract = "Humans are infected with viruses that establish long-term persistent infections. To address whether immunocompetent individuals control virus reactivation globally or independently and to identify patterns of sporadic reactivation, we monitored herpesviruses and polyomaviruses in 30 adults, over 14 months. Epstein-Barr virus (EBV) DNA was quantitated in saliva and peripheral blood mononuclear cells (PBMCs), cytomegalovirus (CMV) was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs. All individuals shed EBV in saliva, whereas 67% had ≥1 blood sample positive for EBV. Levels of EBV varied widely. CMV shedding occurred infrequently but occurred more commonly in younger individuals (P < .03). JCV and BKV virurias were 46.7% and 0%, respectively. JCV shedding was age dependent and occurred commonly in individuals ≥40 years old (P < .03). Seasonal variation was observed in shedding of EBV and JCV, but there was no correlation among shedding of EBV, CMV, and JCV (P > .50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations.",

author = "Ling, {Paul D.} and Lednicky, {John A.} and Keitel, {Wendy A.} and Poston, {David G.} and White, {Zoe S.} and Peng, {Rong Sheng} and Zhensheng Liu and Mehta, {Satish K.} and Pierson, {Duane L.} and Rooney, {Cliona M.} and Vilchez, {Regis A.} and Smith, {E. O.Brian} and Butel, {Janet S.}",

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AU - Rooney, Cliona M.

AU - Vilchez, Regis A.

AU - Smith, E. O.Brian

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AB - Humans are infected with viruses that establish long-term persistent infections. To address whether immunocompetent individuals control virus reactivation globally or independently and to identify patterns of sporadic reactivation, we monitored herpesviruses and polyomaviruses in 30 adults, over 14 months. Epstein-Barr virus (EBV) DNA was quantitated in saliva and peripheral blood mononuclear cells (PBMCs), cytomegalovirus (CMV) was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs. All individuals shed EBV in saliva, whereas 67% had ≥1 blood sample positive for EBV. Levels of EBV varied widely. CMV shedding occurred infrequently but occurred more commonly in younger individuals (P < .03). JCV and BKV virurias were 46.7% and 0%, respectively. JCV shedding was age dependent and occurred commonly in individuals ≥40 years old (P < .03). Seasonal variation was observed in shedding of EBV and JCV, but there was no correlation among shedding of EBV, CMV, and JCV (P > .50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations.

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The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: A 14-month longitudinal study

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