Abstract
In this study the relationship between 6-hydroxydopamine lesions of dopaminergic innervation of the lateral septum and schedule-induced polydipsia was examined. Animals with lesions were found to have a significant increase in water intake during a test involving an intermittent schedule of food delivery. Additional experiments with these animals showed that lesions had no effect on: (i) spontaneous drinking, the amount of drinking after 24 h food or water deprivation, water intake following a hypertonic saline challenge; (ii) eating behavior with or without food deprivation; and (iii) spontaneous locomotor activity. This increase in adjunctive behavior is discussed in the light of an enhanced frustrative effect induced by the septal lesions.
Original language | English (US) |
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Pages (from-to) | 1-8 |
Number of pages | 8 |
Journal | Behavioural Brain Research |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1985 |
Externally published | Yes |
Keywords
- 6-hydroxydopamine
- dopamine
- lateral septum
- lesion
- rat
- schedule-induced polydipsia
ASJC Scopus subject areas
- Behavioral Neuroscience