TY - JOUR
T1 - The effect of antiepileptic drugs on coagulation and bleeding in the perioperative period of epilepsy surgery
T2 - The Cleveland Clinic experience
AU - Manohar, Crystal
AU - Avitsian, Rafi
AU - Lozano, Sara
AU - Gonzalez-Martinez, Jorge
AU - Cata, Juan P.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/9
Y1 - 2011/9
N2 - Antiepileptic drugs (AED) are known to cause coagulation disturbances. We retrospectively analyzed the effect of AED on coagulation parameters in children who underwent craniotomy for epilepsy surgery. A total of 84 children were included. Perioperative coagulation parameters, the number and type of AED, estimated blood loss and the amount of blood products transfused were recorded. The most commonly used AED was lamotrigine. Of all patients, 7.1% were taking valproate. None of the patients showed significantly abnormal prothrombin time, activated partial thromboplastin time, or platelet count preoperatively. Thirty-eight percent of patients were transfused with allogeneic red blood cells and 4.7% of all patients showed significant coagulopathy intraoperatively and postoperatively. We concluded that the number of AED does not appear to be associated with preoperative coagulation disorders or blood transfusion requirements. However, caution should be taken in patients taking AED who undergo complex brain epilepsy surgery due to the potential for significant blood loss.
AB - Antiepileptic drugs (AED) are known to cause coagulation disturbances. We retrospectively analyzed the effect of AED on coagulation parameters in children who underwent craniotomy for epilepsy surgery. A total of 84 children were included. Perioperative coagulation parameters, the number and type of AED, estimated blood loss and the amount of blood products transfused were recorded. The most commonly used AED was lamotrigine. Of all patients, 7.1% were taking valproate. None of the patients showed significantly abnormal prothrombin time, activated partial thromboplastin time, or platelet count preoperatively. Thirty-eight percent of patients were transfused with allogeneic red blood cells and 4.7% of all patients showed significant coagulopathy intraoperatively and postoperatively. We concluded that the number of AED does not appear to be associated with preoperative coagulation disorders or blood transfusion requirements. However, caution should be taken in patients taking AED who undergo complex brain epilepsy surgery due to the potential for significant blood loss.
KW - Antiepileptic drugs
KW - Blood transfusion
KW - Coagulopathy
KW - Epilepsy surgery
KW - Intraoperative bleeding
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U2 - 10.1016/j.jocn.2011.02.018
DO - 10.1016/j.jocn.2011.02.018
M3 - Article
C2 - 21757355
AN - SCOPUS:79961007494
SN - 0967-5868
VL - 18
SP - 1180
EP - 1184
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 9
ER -