Abstract
Introduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous. Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects. Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was conducted through September 2017. Search terms included: “hypoglycemia”,“ insulin” “cytokines” and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans. Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers. Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypoglycemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-50 |
| Number of pages | 10 |
| Journal | Brain, behavior, and immunity |
| Volume | 73 |
| DOIs | |
| State | Published - Oct 2018 |
Keywords
- Hypoglycemia
- Inflammation
- Insulin
ASJC Scopus subject areas
- Immunology
- Endocrine and Autonomic Systems
- Behavioral Neuroscience