The effect of proccessing temperature on mechanical properties of novel silk fibroin and chitosan blend scaffolds for musculoskeletal regeneration

C. N. Rios; J. N. Augustine; A. B. Mathur

The effect of proccessing temperature on mechanical properties of novel silk fibroin and chitosan blend scaffolds for musculoskeletal regeneration

C. N. Rios, J. N. Augustine, A. B. Mathur

Plastic Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanical strength of nine different silk fibroin and chitosan (SFCS) blend scaffolds consisting of 25:75, 50:50 and 75:25 SF:CS, that were processed at the temperatures of -20°C (N=5), -80°C (N=4) and -190°C, was studied. Stress vs. strain curves were obtained using a 1000g load cell. Elastic moduli and ultimate tensile strength data were determined for all samples and statistically analyzed using one-way ANOVA. The ultimate tensile strengths were similar for 50:50 and 75:25 blend scaffolds prepared by the three freezing temperatures. SFCS blend of 25:75 ratio prepared at -190°C was twice as strong as compared to the 25:75 blend scaffolds prepared at -20°C and -80°C (p<0.05). The elastic moduli of the 25:75 and 75:25 blend scaffolds prepared at -20°C were significantly higher than those prepared at -80°C (p < 0.01 and p < 0.05).

Original language	English (US)
Pages (from-to)	173-174
Number of pages	2
Journal	MCB Molecular and Cellular Biomechanics
Volume	3
Issue number	4
State	Published - Dec 2006

ASJC Scopus subject areas

Biophysics
Molecular Medicine
Molecular Biology
Cell Biology

Cite this

@article{4a4070e21a014533aea0f3fe596758d2,

title = "The effect of proccessing temperature on mechanical properties of novel silk fibroin and chitosan blend scaffolds for musculoskeletal regeneration",

abstract = "The mechanical strength of nine different silk fibroin and chitosan (SFCS) blend scaffolds consisting of 25:75, 50:50 and 75:25 SF:CS, that were processed at the temperatures of -20°C (N=5), -80°C (N=4) and -190°C, was studied. Stress vs. strain curves were obtained using a 1000g load cell. Elastic moduli and ultimate tensile strength data were determined for all samples and statistically analyzed using one-way ANOVA. The ultimate tensile strengths were similar for 50:50 and 75:25 blend scaffolds prepared by the three freezing temperatures. SFCS blend of 25:75 ratio prepared at -190°C was twice as strong as compared to the 25:75 blend scaffolds prepared at -20°C and -80°C (p<0.05). The elastic moduli of the 25:75 and 75:25 blend scaffolds prepared at -20°C were significantly higher than those prepared at -80°C (p < 0.01 and p < 0.05).",

author = "Rios, {C. N.} and Augustine, {J. N.} and Mathur, {A. B.}",

year = "2006",

month = dec,

language = "English (US)",

volume = "3",

pages = "173--174",

journal = "MCB Molecular and Cellular Biomechanics",

issn = "1556-5297",

publisher = "Tech Science Press",

number = "4",

}

TY - JOUR

T1 - The effect of proccessing temperature on mechanical properties of novel silk fibroin and chitosan blend scaffolds for musculoskeletal regeneration

AU - Rios, C. N.

AU - Augustine, J. N.

AU - Mathur, A. B.

PY - 2006/12

Y1 - 2006/12

N2 - The mechanical strength of nine different silk fibroin and chitosan (SFCS) blend scaffolds consisting of 25:75, 50:50 and 75:25 SF:CS, that were processed at the temperatures of -20°C (N=5), -80°C (N=4) and -190°C, was studied. Stress vs. strain curves were obtained using a 1000g load cell. Elastic moduli and ultimate tensile strength data were determined for all samples and statistically analyzed using one-way ANOVA. The ultimate tensile strengths were similar for 50:50 and 75:25 blend scaffolds prepared by the three freezing temperatures. SFCS blend of 25:75 ratio prepared at -190°C was twice as strong as compared to the 25:75 blend scaffolds prepared at -20°C and -80°C (p<0.05). The elastic moduli of the 25:75 and 75:25 blend scaffolds prepared at -20°C were significantly higher than those prepared at -80°C (p < 0.01 and p < 0.05).

AB - The mechanical strength of nine different silk fibroin and chitosan (SFCS) blend scaffolds consisting of 25:75, 50:50 and 75:25 SF:CS, that were processed at the temperatures of -20°C (N=5), -80°C (N=4) and -190°C, was studied. Stress vs. strain curves were obtained using a 1000g load cell. Elastic moduli and ultimate tensile strength data were determined for all samples and statistically analyzed using one-way ANOVA. The ultimate tensile strengths were similar for 50:50 and 75:25 blend scaffolds prepared by the three freezing temperatures. SFCS blend of 25:75 ratio prepared at -190°C was twice as strong as compared to the 25:75 blend scaffolds prepared at -20°C and -80°C (p<0.05). The elastic moduli of the 25:75 and 75:25 blend scaffolds prepared at -20°C were significantly higher than those prepared at -80°C (p < 0.01 and p < 0.05).

UR - http://www.scopus.com/inward/record.url?scp=33846407970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846407970&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33846407970

SN - 1556-5297

VL - 3

SP - 173

EP - 174

JO - MCB Molecular and Cellular Biomechanics

JF - MCB Molecular and Cellular Biomechanics

IS - 4

ER -

The effect of proccessing temperature on mechanical properties of novel silk fibroin and chitosan blend scaffolds for musculoskeletal regeneration

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this