The effect of the JAK2 V617F mutation on PRV-1 expression

Zakar Mnjoyan; Donghoon Yoon; Jun Li; François Delhommeau; Vahid Afshar-Kharghan

The effect of the JAK2 V617F mutation on PRV-1 expression

Zakar Mnjoyan, Donghoon Yoon, Jun Li, François Delhommeau, Vahid Afshar-Kharghan

Pulmonary Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

JAK2^V617F, an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2^V617F on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2 ^V617F increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F-induced increase in PRV-1 expression.

Original language	English (US)
Pages (from-to)	411-412
Number of pages	2
Journal	Haematologica
Volume	91
Issue number	3
State	Published - Mar 2006

Keywords

JAK2
Myeloproliferative disorders
PRV-1

ASJC Scopus subject areas

Hematology

Cite this

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title = "The effect of the JAK2 V617F mutation on PRV-1 expression",

abstract = "JAK2V617F, an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2V617F on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2 V617F increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F-induced increase in PRV-1 expression.",

keywords = "JAK2, Myeloproliferative disorders, PRV-1",

author = "Zakar Mnjoyan and Donghoon Yoon and Jun Li and Fran{\c c}ois Delhommeau and Vahid Afshar-Kharghan",

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T1 - The effect of the JAK2 V617F mutation on PRV-1 expression

AU - Mnjoyan, Zakar

AU - Yoon, Donghoon

AU - Li, Jun

AU - Delhommeau, François

AU - Afshar-Kharghan, Vahid

PY - 2006/3

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N2 - JAK2V617F, an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2V617F on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2 V617F increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F-induced increase in PRV-1 expression.

AB - JAK2V617F, an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2V617F on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2 V617F increased both PRV-1 protein and mRNA levels in murine myeloid cells. A JAK2 inhibitor eliminated the V617F-induced increase in PRV-1 expression.

KW - JAK2

KW - Myeloproliferative disorders

KW - PRV-1

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The effect of the JAK2 V617F mutation on PRV-1 expression

Abstract

Keywords

ASJC Scopus subject areas

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