The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat

Alan R. Boobis; Garth Powis

doi:10.1016/0006-2952(74)90340-2

The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat

Alan R. Boobis, Garth Powis

Experimental Therapeutics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Adrenaline and noradrenaline 6 μM, inhibited the rate of hexobarbitone metabolism by the isolated rat liver perfused at a constant flow rate, by a maximum of 62 and 54 per cent respectively. Neither catecholamine had any significant effect upon the metabolism of aniline. Hexobarbitone and aniline metabolism by rat liver slices was unaffected by either adrenaline or noradrenaline. It is suggested that the differential effect of adrenaline upon the metabolism of foreign compounds by the perfused liver is due to a partial hypoxia, which may be a result of the observed redistribution of perfusate away from some areas of the liver at the periphery of the lobes.

Original language	English (US)
Pages (from-to)	3377-3382,in1-in2,3383-3384
Journal	Biochemical Pharmacology
Volume	23
Issue number	24
DOIs	https://doi.org/10.1016/0006-2952(74)90340-2
State	Published - Dec 15 1974

ASJC Scopus subject areas

Biochemistry
Pharmacology

Access to Document

10.1016/0006-2952(74)90340-2

Cite this

@article{40837563d5824998be4a205821611ecd,

title = "The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat",

abstract = "Adrenaline and noradrenaline 6 μM, inhibited the rate of hexobarbitone metabolism by the isolated rat liver perfused at a constant flow rate, by a maximum of 62 and 54 per cent respectively. Neither catecholamine had any significant effect upon the metabolism of aniline. Hexobarbitone and aniline metabolism by rat liver slices was unaffected by either adrenaline or noradrenaline. It is suggested that the differential effect of adrenaline upon the metabolism of foreign compounds by the perfused liver is due to a partial hypoxia, which may be a result of the observed redistribution of perfusate away from some areas of the liver at the periphery of the lobes.",

author = "Boobis, {Alan R.} and Garth Powis",

note = "Funding Information: Ackn0wledgement~A.R.B. is a Medical Research Council scholar. We are also grateful for a grant from the Medical Research Funds of Glasgow University and for the supply of aged human red blood cells by the West of Scotland Regional Blood Transfusion Service.",

year = "1974",

month = dec,

day = "15",

doi = "10.1016/0006-2952(74)90340-2",

language = "English (US)",

volume = "23",

pages = "3377--3382,in1--in2,3383--3384",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

number = "24",

}

TY - JOUR

T1 - The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat

AU - Boobis, Alan R.

AU - Powis, Garth

N1 - Funding Information: Ackn0wledgement~A.R.B. is a Medical Research Council scholar. We are also grateful for a grant from the Medical Research Funds of Glasgow University and for the supply of aged human red blood cells by the West of Scotland Regional Blood Transfusion Service.

PY - 1974/12/15

Y1 - 1974/12/15

N2 - Adrenaline and noradrenaline 6 μM, inhibited the rate of hexobarbitone metabolism by the isolated rat liver perfused at a constant flow rate, by a maximum of 62 and 54 per cent respectively. Neither catecholamine had any significant effect upon the metabolism of aniline. Hexobarbitone and aniline metabolism by rat liver slices was unaffected by either adrenaline or noradrenaline. It is suggested that the differential effect of adrenaline upon the metabolism of foreign compounds by the perfused liver is due to a partial hypoxia, which may be a result of the observed redistribution of perfusate away from some areas of the liver at the periphery of the lobes.

AB - Adrenaline and noradrenaline 6 μM, inhibited the rate of hexobarbitone metabolism by the isolated rat liver perfused at a constant flow rate, by a maximum of 62 and 54 per cent respectively. Neither catecholamine had any significant effect upon the metabolism of aniline. Hexobarbitone and aniline metabolism by rat liver slices was unaffected by either adrenaline or noradrenaline. It is suggested that the differential effect of adrenaline upon the metabolism of foreign compounds by the perfused liver is due to a partial hypoxia, which may be a result of the observed redistribution of perfusate away from some areas of the liver at the periphery of the lobes.

UR - http://www.scopus.com/inward/record.url?scp=0016178318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016178318&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(74)90340-2

DO - 10.1016/0006-2952(74)90340-2

M3 - Article

C2 - 4374219

AN - SCOPUS:0016178318

SN - 0006-2952

VL - 23

SP - 3377-3382,in1-in2,3383-3384

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 24

ER -

The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this