The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium

G. Illiano; R. Galderisi; A. Di Donato; G. Paolisso; G. F. Draetta

doi:10.1016/0306-3623(85)90046-1

The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium

G. Illiano, R. Galderisi, A. Di Donato, G. Paolisso, G. F. Draetta

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Abstract

1. 1. The incubation of rat myocardial sarcolemmal membranes with 10^-4 M lidocaine or procainamide results in a decreased fluorescence polarization of the extrinsic probes (diphenylhexatriene and 12-anthroylstearate) and in the stimulation of the membrane-bound high affinity cyclic AMP phosphodiesterase activity (PDE). 2. 2. Lidocaine or procainamide do not contrast, but facilitate the aminophylline inhibitory action on the PDE activity, without modifying the basic molecular mechanism of the inhibitory action. 3. 3. The amplitudes of the effects described are inversely correlated to the temperature, being greater at the lower tested temperature (25° > 30° > 37°C).

Original language	English (US)
Pages (from-to)	115-119
Number of pages	5
Journal	General Pharmacology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0306-3623(85)90046-1
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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title = "The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium",

abstract = "1. 1. The incubation of rat myocardial sarcolemmal membranes with 10-4 M lidocaine or procainamide results in a decreased fluorescence polarization of the extrinsic probes (diphenylhexatriene and 12-anthroylstearate) and in the stimulation of the membrane-bound high affinity cyclic AMP phosphodiesterase activity (PDE). 2. 2. Lidocaine or procainamide do not contrast, but facilitate the aminophylline inhibitory action on the PDE activity, without modifying the basic molecular mechanism of the inhibitory action. 3. 3. The amplitudes of the effects described are inversely correlated to the temperature, being greater at the lower tested temperature (25° > 30° > 37°C).",

author = "G. Illiano and R. Galderisi and {Di Donato}, A. and G. Paolisso and Draetta, {G. F.}",

year = "1985",

doi = "10.1016/0306-3623(85)90046-1",

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pages = "115--119",

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T1 - The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium

AU - Illiano, G.

AU - Galderisi, R.

AU - Di Donato, A.

AU - Paolisso, G.

AU - Draetta, G. F.

PY - 1985

Y1 - 1985

N2 - 1. 1. The incubation of rat myocardial sarcolemmal membranes with 10-4 M lidocaine or procainamide results in a decreased fluorescence polarization of the extrinsic probes (diphenylhexatriene and 12-anthroylstearate) and in the stimulation of the membrane-bound high affinity cyclic AMP phosphodiesterase activity (PDE). 2. 2. Lidocaine or procainamide do not contrast, but facilitate the aminophylline inhibitory action on the PDE activity, without modifying the basic molecular mechanism of the inhibitory action. 3. 3. The amplitudes of the effects described are inversely correlated to the temperature, being greater at the lower tested temperature (25° > 30° > 37°C).

AB - 1. 1. The incubation of rat myocardial sarcolemmal membranes with 10-4 M lidocaine or procainamide results in a decreased fluorescence polarization of the extrinsic probes (diphenylhexatriene and 12-anthroylstearate) and in the stimulation of the membrane-bound high affinity cyclic AMP phosphodiesterase activity (PDE). 2. 2. Lidocaine or procainamide do not contrast, but facilitate the aminophylline inhibitory action on the PDE activity, without modifying the basic molecular mechanism of the inhibitory action. 3. 3. The amplitudes of the effects described are inversely correlated to the temperature, being greater at the lower tested temperature (25° > 30° > 37°C).

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DO - 10.1016/0306-3623(85)90046-1

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JO - General Pharmacology

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The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium

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