The emerging roles of F-box proteins in pancreatic tumorigenesis

Hua Wang; Anirban Maitra; Huamin Wang

doi:10.1016/j.semcancer.2015.09.004

The emerging roles of F-box proteins in pancreatic tumorigenesis

Hua Wang, Anirban Maitra, Huamin Wang

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.

Original language	English (US)
Pages (from-to)	88-94
Number of pages	7
Journal	Seminars in cancer biology
Volume	36
DOIs	https://doi.org/10.1016/j.semcancer.2015.09.004
State	Published - Feb 1 2016

Keywords

F-box proteins
Fbxw7
Fbxw8
Pancreatic cancer
β-TrCP

ASJC Scopus subject areas

Cancer Research

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10.1016/j.semcancer.2015.09.004

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title = "The emerging roles of F-box proteins in pancreatic tumorigenesis",

abstract = "The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.",

keywords = "F-box proteins, Fbxw7, Fbxw8, Pancreatic cancer, β-TrCP",

author = "Hua Wang and Anirban Maitra and Huamin Wang",

note = "Funding Information: Supported by the National Institutes of Health though grant(1R21CA149544-01A1), the G.S. Hogan Gastrointestinal Cancer Research Fund, and Khalifa Bin Zayed Al Nahyan Foundation Insti-tute for Pancreatic Cancer Research at the University of Texas M.D.Anderson Cancer Center. Funding Information: Supported by the National Institutes of Health though grant ( 1R21CA149544-01A1 ), the G.S. Hogan Gastrointestinal Cancer Research Fund , and Khalifa Bin Zayed Al Nahyan Foundation Institute for Pancreatic Cancer Research at the University of Texas M.D. Anderson Cancer Center . Publisher Copyright: {\textcopyright} 2015.",

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doi = "10.1016/j.semcancer.2015.09.004",

language = "English (US)",

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AU - Maitra, Anirban

AU - Wang, Huamin

N1 - Funding Information: Supported by the National Institutes of Health though grant(1R21CA149544-01A1), the G.S. Hogan Gastrointestinal Cancer Research Fund, and Khalifa Bin Zayed Al Nahyan Foundation Insti-tute for Pancreatic Cancer Research at the University of Texas M.D.Anderson Cancer Center. Funding Information: Supported by the National Institutes of Health though grant ( 1R21CA149544-01A1 ), the G.S. Hogan Gastrointestinal Cancer Research Fund , and Khalifa Bin Zayed Al Nahyan Foundation Institute for Pancreatic Cancer Research at the University of Texas M.D. Anderson Cancer Center . Publisher Copyright: © 2015.

PY - 2016/2/1

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N2 - The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.

AB - The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.

KW - F-box proteins

KW - Fbxw7

KW - Fbxw8

KW - Pancreatic cancer

KW - β-TrCP

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The emerging roles of F-box proteins in pancreatic tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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