Abstract
This perspective will focus on the physiological impact of wild-type and mutant p53 activities. In particular, the tissue-specific nature of activation of p53 targets and their subsequent effects on cell behavior will be discussed. Because mutations in p53 are common in human cancers, the regulation and physiological consequences of mutant p53 proteins will also be discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 37-40 |
| Number of pages | 4 |
| Journal | Cold Spring Harbor symposia on quantitative biology |
| Volume | 81 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2016 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics