TY - JOUR
T1 - The epidemic of HVP-associated oropharyngeal cancer is here
T2 - Is it time to change our treatment paradigms?
AU - Sturgis, Erich M.
AU - Ang, K. Kian
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Although relatively uncommon, oropharyngeal cancers are increasing in incidence despite declining prevalence of smoking and in direct opposition to a decreasing incidence of all other head and neck cancers. An epidemic of human papillomavirus (HPV)-associated oropharyngeal cancers seems to account for these incidence trends. Important demographic, behavioral, and prognostic characteristics define this unique population. Changes in prevention, diagnosis, evaluation, staging, and treatment are needed. This article summarizes the epidemiology and clinical behavior of HPV-associated oropharyngeal cancer and discusses evolving/potential paradigms of treatment. However, data are currently insufficient to change treatment paradigms for HPV-associated oropharyngeal cancer outside of a closely monitored clinical trial.
AB - Although relatively uncommon, oropharyngeal cancers are increasing in incidence despite declining prevalence of smoking and in direct opposition to a decreasing incidence of all other head and neck cancers. An epidemic of human papillomavirus (HPV)-associated oropharyngeal cancers seems to account for these incidence trends. Important demographic, behavioral, and prognostic characteristics define this unique population. Changes in prevention, diagnosis, evaluation, staging, and treatment are needed. This article summarizes the epidemiology and clinical behavior of HPV-associated oropharyngeal cancer and discusses evolving/potential paradigms of treatment. However, data are currently insufficient to change treatment paradigms for HPV-associated oropharyngeal cancer outside of a closely monitored clinical trial.
KW - Epidemiology
KW - Head and neck cancer
KW - Human papillomavirus
KW - Oral cancer
KW - Oropharyngeal cancer
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=79957867260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957867260&partnerID=8YFLogxK
U2 - 10.6004/jnccn.2011.0055
DO - 10.6004/jnccn.2011.0055
M3 - Review article
C2 - 21636538
AN - SCOPUS:79957867260
SN - 1540-1405
VL - 9
SP - 665
EP - 673
JO - JNCCN Journal of the National Comprehensive Cancer Network
JF - JNCCN Journal of the National Comprehensive Cancer Network
IS - 6
ER -