The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors

Valerie Rusch; John Mendelsohn; Ethan Dmitrovsky

doi:10.1016/1359-6101(96)00016-0

The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors

Valerie Rusch, John Mendelsohn, Ethan Dmitrovsky

Research output: Contribution to journal › Short survey › peer-review

99 Scopus citations

Abstract

The epidermal growth factor receptor (EGFR) is detected on many non- haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-α, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.

Original language	English (US)
Pages (from-to)	133-141
Number of pages	9
Journal	Cytokine and Growth Factor Reviews
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/1359-6101(96)00016-0
State	Published - Aug 1996

Keywords

EGFR
Human tumors
Ligands
Therapeutic targets

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

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abstract = "The epidermal growth factor receptor (EGFR) is detected on many non- haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-α, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.",

keywords = "EGFR, Human tumors, Ligands, Therapeutic targets",

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AU - Mendelsohn, John

AU - Dmitrovsky, Ethan

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AB - The epidermal growth factor receptor (EGFR) is detected on many non- haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-α, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.

KW - EGFR

KW - Human tumors

KW - Ligands

KW - Therapeutic targets

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The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors

Abstract

Keywords

ASJC Scopus subject areas

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