TY - JOUR
T1 - The epigenetic dysfunction underlying malignant glioma pathogenesis
AU - Dharmaiah, Sharvari
AU - Huse, Jason T.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to United States and Canadian Academy of Pathology.
PY - 2022/7
Y1 - 2022/7
N2 - Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and deadly brain tumor variants, are now classified by highly recurrent biomarkers instead of histomorphological characteristics. Several of the key molecular alterations driving glioma classification involve epigenetic dysregulation at a fundamental level, implicating fields of biology not previously thought to play major roles glioma pathogenesis. This article will review the major epigenetic alterations underlying malignant gliomas, their likely mechanisms of action, and potential strategies for their therapeutic targeting.
AB - Comprehensive molecular profiling has dramatically transformed the diagnostic neuropathology of brain tumors. Diffuse gliomas, the most common and deadly brain tumor variants, are now classified by highly recurrent biomarkers instead of histomorphological characteristics. Several of the key molecular alterations driving glioma classification involve epigenetic dysregulation at a fundamental level, implicating fields of biology not previously thought to play major roles glioma pathogenesis. This article will review the major epigenetic alterations underlying malignant gliomas, their likely mechanisms of action, and potential strategies for their therapeutic targeting.
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U2 - 10.1038/s41374-022-00741-7
DO - 10.1038/s41374-022-00741-7
M3 - Review article
C2 - 35152274
AN - SCOPUS:85124666756
SN - 0023-6837
VL - 102
SP - 682
EP - 690
JO - Laboratory Investigation
JF - Laboratory Investigation
IS - 7
ER -