Abstract
Administration of o, p1-DDT to immature female rats causes a translocation of estrogen receptors to uterine nuclei which is maximum 3 hours after pesticide treatment, and a subsequent increase in uterine weight at 24 hours. A high degree of correlation (r = 0.98) exists between the level of nuclear estrogen receptor and increases in uterine weight measured 3 and 24 hours respectively after administration of o, p1-DDT, in the dose range of 10-1000 mg/kg. This high degree of correlation between these two parameters lends strong support to the hypothesis that the estrogenic effects observed following in vivo administration of o, p1-DDT result from the interaction of the pesticide with the classical estrogen receptor system.
Original language | English (US) |
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Pages (from-to) | 2479-2484 |
Number of pages | 6 |
Journal | Life Sciences |
Volume | 31 |
Issue number | 22 |
DOIs | |
State | Published - Nov 29 1982 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- Pharmacology, Toxicology and Pharmaceutics(all)