The estrogenic activity of DDT: Invivo and invitro induction of a specific estrogen inducible uterine protein by o,p'-DDT

George M. Stancel; Judy S. Ireland; Venkat R. Mukku; Alice K. Robison

doi:10.1016/0024-3205(80)90037-5

The estrogenic activity of DDT: Invivo and invitro induction of a specific estrogen inducible uterine protein by o,p'-DDT

George M. Stancel, Judy S. Ireland, Venkat R. Mukku, Alice K. Robison

Gynecological Oncology & Reproductive Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The pesticide o,p'-DDT stimulates the production of a specific uterine protein, the so-called induced protein or IP, normally associated with an estrogenic response of the uterus. Invivo stimulation of IP production is observed 1 hour after the administration of 250 mg/kg of o,p'-DDT to immature rats. Invitro stimulation of IP production is observed after a 1 hour incubation of uteri with 100 μM o,p'-DDT. This invitro response is blocked by Actinomycin D. In contrast to o,p'-DDT, which binds to the cytoplasmic estrogen receptor and stimulates IP production, p,p'-DDT which does not bind well to the estrogen receptor does not stimulate IP production invitro. These findings represent the first report of an estrogenic effect of o,p'-DDT in a completely invitro system.

Original language	English (US)
Pages (from-to)	1111-1117
Number of pages	7
Journal	Life Sciences
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(80)90037-5
State	Published - 1980

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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@article{230eb93478cc4dbdacfbf69a78b02941,

title = "The estrogenic activity of DDT: Invivo and invitro induction of a specific estrogen inducible uterine protein by o,p'-DDT",

abstract = "The pesticide o,p'-DDT stimulates the production of a specific uterine protein, the so-called induced protein or IP, normally associated with an estrogenic response of the uterus. Invivo stimulation of IP production is observed 1 hour after the administration of 250 mg/kg of o,p'-DDT to immature rats. Invitro stimulation of IP production is observed after a 1 hour incubation of uteri with 100 μM o,p'-DDT. This invitro response is blocked by Actinomycin D. In contrast to o,p'-DDT, which binds to the cytoplasmic estrogen receptor and stimulates IP production, p,p'-DDT which does not bind well to the estrogen receptor does not stimulate IP production invitro. These findings represent the first report of an estrogenic effect of o,p'-DDT in a completely invitro system.",

author = "Stancel, {George M.} and Ireland, {Judy S.} and Mukku, {Venkat R.} and Robison, {Alice K.}",

note = "Funding Information: This work was supported by NIH grant HD-08615. G.M.S. is a recipient of a Research Career Development Award (HD-00099).",

year = "1980",

doi = "10.1016/0024-3205(80)90037-5",

language = "English (US)",

volume = "27",

pages = "1111--1117",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

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T1 - The estrogenic activity of DDT

T2 - Invivo and invitro induction of a specific estrogen inducible uterine protein by o,p'-DDT

AU - Stancel, George M.

AU - Ireland, Judy S.

AU - Mukku, Venkat R.

AU - Robison, Alice K.

N1 - Funding Information: This work was supported by NIH grant HD-08615. G.M.S. is a recipient of a Research Career Development Award (HD-00099).

PY - 1980

Y1 - 1980

N2 - The pesticide o,p'-DDT stimulates the production of a specific uterine protein, the so-called induced protein or IP, normally associated with an estrogenic response of the uterus. Invivo stimulation of IP production is observed 1 hour after the administration of 250 mg/kg of o,p'-DDT to immature rats. Invitro stimulation of IP production is observed after a 1 hour incubation of uteri with 100 μM o,p'-DDT. This invitro response is blocked by Actinomycin D. In contrast to o,p'-DDT, which binds to the cytoplasmic estrogen receptor and stimulates IP production, p,p'-DDT which does not bind well to the estrogen receptor does not stimulate IP production invitro. These findings represent the first report of an estrogenic effect of o,p'-DDT in a completely invitro system.

AB - The pesticide o,p'-DDT stimulates the production of a specific uterine protein, the so-called induced protein or IP, normally associated with an estrogenic response of the uterus. Invivo stimulation of IP production is observed 1 hour after the administration of 250 mg/kg of o,p'-DDT to immature rats. Invitro stimulation of IP production is observed after a 1 hour incubation of uteri with 100 μM o,p'-DDT. This invitro response is blocked by Actinomycin D. In contrast to o,p'-DDT, which binds to the cytoplasmic estrogen receptor and stimulates IP production, p,p'-DDT which does not bind well to the estrogen receptor does not stimulate IP production invitro. These findings represent the first report of an estrogenic effect of o,p'-DDT in a completely invitro system.

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The estrogenic activity of DDT: Invivo and invitro induction of a specific estrogen inducible uterine protein by o,p'-DDT

Abstract

ASJC Scopus subject areas

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