The fanconi anemia pathway and interstrand cross-link repair

Masamichi Ishiai; Junya Tomida; Akiko Itaya; James Hejna; Minoru Takata

doi:10.1007/978-4-431-55873-6_8

The fanconi anemia pathway and interstrand cross-link repair

Masamichi Ishiai, Junya Tomida, Akiko Itaya, James Hejna, Minoru Takata

Epigenetics & Molecular Carcinogenesis

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Fanconi anemia (FA) is a hereditary disorder characterized by bone marrow failure and genome instability that is ascribed to defective DNA interstrand cross-link (ICL) repair. In this chapter we summarize our current understanding of the function of the FA genes, the mechanism for FA pathway activation, and the processes of ICL repair in the cell. In addition, we will highlight recent evidence that implicates endogenous aldehydes in creating genomic damage in FA cells, culminating in the FA phenotypes.

Original language	English (US)
Title of host publication	DNA Replication, Recombination, and Repair
Subtitle of host publication	Molecular Mechanisms and Pathology
Publisher	Springer Japan
Pages	175-210
Number of pages	36
ISBN (Electronic)	9784431558736
ISBN (Print)	9784431558712
DOIs	https://doi.org/10.1007/978-4-431-55873-6_8
State	Published - Jan 1 2016

Keywords

Aldehydes
Aldh2
Atr-atrip kinase
Fancd2
Fanconi anemia
Interstrand cross-link

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1007/978-4-431-55873-6_8

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abstract = "Fanconi anemia (FA) is a hereditary disorder characterized by bone marrow failure and genome instability that is ascribed to defective DNA interstrand cross-link (ICL) repair. In this chapter we summarize our current understanding of the function of the FA genes, the mechanism for FA pathway activation, and the processes of ICL repair in the cell. In addition, we will highlight recent evidence that implicates endogenous aldehydes in creating genomic damage in FA cells, culminating in the FA phenotypes.",

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T1 - The fanconi anemia pathway and interstrand cross-link repair

AU - Ishiai, Masamichi

AU - Tomida, Junya

AU - Itaya, Akiko

AU - Hejna, James

AU - Takata, Minoru

N1 - Publisher Copyright: © Springer Japan 2016.

PY - 2016/1/1

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N2 - Fanconi anemia (FA) is a hereditary disorder characterized by bone marrow failure and genome instability that is ascribed to defective DNA interstrand cross-link (ICL) repair. In this chapter we summarize our current understanding of the function of the FA genes, the mechanism for FA pathway activation, and the processes of ICL repair in the cell. In addition, we will highlight recent evidence that implicates endogenous aldehydes in creating genomic damage in FA cells, culminating in the FA phenotypes.

AB - Fanconi anemia (FA) is a hereditary disorder characterized by bone marrow failure and genome instability that is ascribed to defective DNA interstrand cross-link (ICL) repair. In this chapter we summarize our current understanding of the function of the FA genes, the mechanism for FA pathway activation, and the processes of ICL repair in the cell. In addition, we will highlight recent evidence that implicates endogenous aldehydes in creating genomic damage in FA cells, culminating in the FA phenotypes.

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KW - Atr-atrip kinase

KW - Fancd2

KW - Fanconi anemia

KW - Interstrand cross-link

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BT - DNA Replication, Recombination, and Repair

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ER -

The fanconi anemia pathway and interstrand cross-link repair

Abstract

Keywords

ASJC Scopus subject areas

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