The fate of lysergic acid di[14C]ethylamide ([14C]LSD) in the rat

Z. H. Siddik; R. D. Barnes; L. G. Dring; R. L. Smith; R. T. Williams

doi:10.1042/bst0030290

The fate of lysergic acid di[¹⁴C]ethylamide ([¹⁴C]LSD) in the rat

Z. H. Siddik, R. D. Barnes, L. G. Dring, R. L. Smith, R. T. Williams

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

It appears that the main route of metabolism of LSD in the rat is by hydroxylation of the benzene ring to form phenols, which are excreted, conjugated with glucuronic acid, mainly in the bile. Deethylation is a minor reaction, but its occurrence is shown by the appearance of a small amount of ¹⁴CO₂ in the expired air of intact rats and the detection of lysergic acid monoethylamide in the perfusate from the liver perfusion. Demethylation is also a minor route, since nor LSD has also been detected in this perfusate.

Original language	English (US)
Pages (from-to)	290-292
Number of pages	3
Journal	Unknown Journal
Volume	3
Issue number	2
DOIs	https://doi.org/10.1042/bst0030290
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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title = "The fate of lysergic acid di[14C]ethylamide ([14C]LSD) in the rat",

abstract = "It appears that the main route of metabolism of LSD in the rat is by hydroxylation of the benzene ring to form phenols, which are excreted, conjugated with glucuronic acid, mainly in the bile. Deethylation is a minor reaction, but its occurrence is shown by the appearance of a small amount of 14CO2 in the expired air of intact rats and the detection of lysergic acid monoethylamide in the perfusate from the liver perfusion. Demethylation is also a minor route, since nor LSD has also been detected in this perfusate.",

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AU - Siddik, Z. H.

AU - Barnes, R. D.

AU - Dring, L. G.

AU - Smith, R. L.

AU - Williams, R. T.

PY - 1975

Y1 - 1975

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AB - It appears that the main route of metabolism of LSD in the rat is by hydroxylation of the benzene ring to form phenols, which are excreted, conjugated with glucuronic acid, mainly in the bile. Deethylation is a minor reaction, but its occurrence is shown by the appearance of a small amount of 14CO2 in the expired air of intact rats and the detection of lysergic acid monoethylamide in the perfusate from the liver perfusion. Demethylation is also a minor route, since nor LSD has also been detected in this perfusate.

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ER -

The fate of lysergic acid di[¹⁴C]ethylamide ([¹⁴C]LSD) in the rat

Abstract

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