The first PET glimpse of a proton FLASH beam

F. Abouzahr; J. P. Cesar; P. Crespo; M. Gajda; Z. Hu; W. Kaye; K. Klein; A. S. Kuo; S. Majewski; O. Mawlawi; A. Morozov; A. Ojha; F. Poenisch; J. C. Polf; M. Proga; N. Sahoo; J. Seco; T. Takaoka; S. Tavernier; U. Titt; X. Wang; X. R. Zhu; K. Lang

doi:10.1088/1361-6560/acd29e

The first PET glimpse of a proton FLASH beam

F. Abouzahr, J. P. Cesar, P. Crespo, M. Gajda, Z. Hu, W. Kaye, K. Klein, A. S. Kuo, S. Majewski, O. Mawlawi, A. Morozov, A. Ojha, F. Poenisch, J. C. Polf, M. Proga, N. Sahoo, J. Seco, T. Takaoka, S. Tavernier, U. TittX. Wang, X. R. Zhu, K. Lang

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 10¹⁰ protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.

Original language	English (US)
Article number	125001
Journal	Physics in medicine and biology
Volume	68
Issue number	12
DOIs	https://doi.org/10.1088/1361-6560/acd29e
State	Published - Jun 21 2023

Keywords

FLASH beam
PET
PET dosimetry
PET imaging
proton therapy
radiation oncology
radiation treatment plan

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1088/1361-6560/acd29e

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Abouzahr, F., Cesar, J. P., Crespo, P., Gajda, M., Hu, Z., Kaye, W., Klein, K., Kuo, A. S., Majewski, S., Mawlawi, O., Morozov, A., Ojha, A., Poenisch, F., Polf, J. C., Proga, M., Sahoo, N., Seco, J., Takaoka, T., Tavernier, S., ... Lang, K. (2023). The first PET glimpse of a proton FLASH beam. Physics in medicine and biology, 68(12), Article 125001. https://doi.org/10.1088/1361-6560/acd29e

Abouzahr, F, Cesar, JP, Crespo, P, Gajda, M, Hu, Z, Kaye, W, Klein, K, Kuo, AS, Majewski, S, Mawlawi, O, Morozov, A, Ojha, A, Poenisch, F, Polf, JC, Proga, M, Sahoo, N, Seco, J, Takaoka, T, Tavernier, S, Titt, U, Wang, X, Zhu, XR & Lang, K 2023, 'The first PET glimpse of a proton FLASH beam', Physics in medicine and biology, vol. 68, no. 12, 125001. https://doi.org/10.1088/1361-6560/acd29e

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title = "The first PET glimpse of a proton FLASH beam",

abstract = "We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 1010 protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.",

keywords = "FLASH beam, PET, PET dosimetry, PET imaging, proton therapy, radiation oncology, radiation treatment plan",

author = "F. Abouzahr and Cesar, {J. P.} and P. Crespo and M. Gajda and Z. Hu and W. Kaye and K. Klein and Kuo, {A. S.} and S. Majewski and O. Mawlawi and A. Morozov and A. Ojha and F. Poenisch and Polf, {J. C.} and M. Proga and N. Sahoo and J. Seco and T. Takaoka and S. Tavernier and U. Titt and X. Wang and Zhu, {X. R.} and K. Lang",

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AU - Abouzahr, F.

AU - Cesar, J. P.

AU - Crespo, P.

AU - Gajda, M.

AU - Hu, Z.

AU - Kaye, W.

AU - Klein, K.

AU - Kuo, A. S.

AU - Majewski, S.

AU - Mawlawi, O.

AU - Morozov, A.

AU - Ojha, A.

AU - Poenisch, F.

AU - Polf, J. C.

AU - Proga, M.

AU - Sahoo, N.

AU - Seco, J.

AU - Takaoka, T.

AU - Tavernier, S.

AU - Titt, U.

AU - Wang, X.

AU - Zhu, X. R.

AU - Lang, K.

PY - 2023/6/21

Y1 - 2023/6/21

N2 - We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 1010 protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.

AB - We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 1010 protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.

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KW - PET

KW - PET dosimetry

KW - PET imaging

KW - proton therapy

KW - radiation oncology

KW - radiation treatment plan

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The first PET glimpse of a proton FLASH beam

Abstract

Keywords

ASJC Scopus subject areas

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