The first probe of a FLASH proton beam by PET

F. Abouzahr; J. P. Cesar; P. Crespo; M. Gajda; Z. Hu; K. Klein; A. S. Kuo; S. Majewski; O. Mawlawi; A. Morozov; A. Ojha; F. Poenisch; M. Proga; N. Sahoo; J. Seco; T. Takaoka; S. Tavernier; U. Titt; X. Wang; X. R. Zhu; K. Lang

doi:10.1088/1361-6560/ad0901

The first probe of a FLASH proton beam by PET

F. Abouzahr, J. P. Cesar, P. Crespo, M. Gajda, Z. Hu, K. Klein, A. S. Kuo, S. Majewski, O. Mawlawi, A. Morozov, A. Ojha, F. Poenisch, M. Proga, N. Sahoo, J. Seco, T. Takaoka, S. Tavernier, U. Titt, X. Wang, X. R. ZhuK. Lang

Research output: Contribution to journal › Article › peer-review

Abstract

The recently observed FLASH effect related to high doses delivered with high rates has the potential to revolutionize radiation cancer therapy if promising results are confirmed and an underlying mechanism understood. Comprehensive measurements are essential to elucidate the phenomenon. We report the first-ever demonstration of measurements of successive in-spill and post-spill emissions of gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography (PET) system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson Cancer Center to view phantoms irradiated by 3.5 × 10¹⁰ protons with a kinetic energy of 75.8 MeV delivered in 101.5 ms-long spills yielding a dose rate of 164 Gy s⁻¹. Most in-spill events were due to prompt gammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitative imaging and dosimetric information. These findings open a new and novel modality for imaging and monitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by post-spill PET imaging.

Original language	English (US)
Article number	235004
Journal	Physics in medicine and biology
Volume	68
Issue number	23
DOIs	https://doi.org/10.1088/1361-6560/ad0901
State	Published - Dec 7 2023

Keywords

FLASH
PET
PET dosimetry
PET imaging
Proton therapy
prompt gammas

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1088/1361-6560/ad0901

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Abouzahr, F., Cesar, J. P., Crespo, P., Gajda, M., Hu, Z., Klein, K., Kuo, A. S., Majewski, S., Mawlawi, O., Morozov, A., Ojha, A., Poenisch, F., Proga, M., Sahoo, N., Seco, J., Takaoka, T., Tavernier, S., Titt, U., Wang, X., ... Lang, K. (2023). The first probe of a FLASH proton beam by PET. Physics in medicine and biology, 68(23), Article 235004. https://doi.org/10.1088/1361-6560/ad0901

Abouzahr, F, Cesar, JP, Crespo, P, Gajda, M, Hu, Z, Klein, K, Kuo, AS, Majewski, S, Mawlawi, O, Morozov, A, Ojha, A, Poenisch, F, Proga, M, Sahoo, N, Seco, J, Takaoka, T, Tavernier, S, Titt, U , Wang, X , Zhu, XR & Lang, K 2023, 'The first probe of a FLASH proton beam by PET', Physics in medicine and biology, vol. 68, no. 23, 235004. https://doi.org/10.1088/1361-6560/ad0901

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abstract = "The recently observed FLASH effect related to high doses delivered with high rates has the potential to revolutionize radiation cancer therapy if promising results are confirmed and an underlying mechanism understood. Comprehensive measurements are essential to elucidate the phenomenon. We report the first-ever demonstration of measurements of successive in-spill and post-spill emissions of gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography (PET) system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson Cancer Center to view phantoms irradiated by 3.5 × 1010 protons with a kinetic energy of 75.8 MeV delivered in 101.5 ms-long spills yielding a dose rate of 164 Gy s−1. Most in-spill events were due to prompt gammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitative imaging and dosimetric information. These findings open a new and novel modality for imaging and monitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by post-spill PET imaging.",

keywords = "FLASH, PET, PET dosimetry, PET imaging, Proton therapy, prompt gammas",

author = "F. Abouzahr and Cesar, {J. P.} and P. Crespo and M. Gajda and Z. Hu and K. Klein and Kuo, {A. S.} and S. Majewski and O. Mawlawi and A. Morozov and A. Ojha and F. Poenisch and M. Proga and N. Sahoo and J. Seco and T. Takaoka and S. Tavernier and U. Titt and X. Wang and Zhu, {X. R.} and K. Lang",

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AU - Abouzahr, F.

AU - Cesar, J. P.

AU - Crespo, P.

AU - Gajda, M.

AU - Hu, Z.

AU - Klein, K.

AU - Kuo, A. S.

AU - Majewski, S.

AU - Mawlawi, O.

AU - Morozov, A.

AU - Ojha, A.

AU - Poenisch, F.

AU - Proga, M.

AU - Sahoo, N.

AU - Seco, J.

AU - Takaoka, T.

AU - Tavernier, S.

AU - Titt, U.

AU - Wang, X.

AU - Zhu, X. R.

AU - Lang, K.

PY - 2023/12/7

Y1 - 2023/12/7

N2 - The recently observed FLASH effect related to high doses delivered with high rates has the potential to revolutionize radiation cancer therapy if promising results are confirmed and an underlying mechanism understood. Comprehensive measurements are essential to elucidate the phenomenon. We report the first-ever demonstration of measurements of successive in-spill and post-spill emissions of gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography (PET) system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson Cancer Center to view phantoms irradiated by 3.5 × 1010 protons with a kinetic energy of 75.8 MeV delivered in 101.5 ms-long spills yielding a dose rate of 164 Gy s−1. Most in-spill events were due to prompt gammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitative imaging and dosimetric information. These findings open a new and novel modality for imaging and monitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by post-spill PET imaging.

AB - The recently observed FLASH effect related to high doses delivered with high rates has the potential to revolutionize radiation cancer therapy if promising results are confirmed and an underlying mechanism understood. Comprehensive measurements are essential to elucidate the phenomenon. We report the first-ever demonstration of measurements of successive in-spill and post-spill emissions of gammas arising from irradiations by a FLASH proton beam. A small positron emission tomography (PET) system was exposed in an ocular beam of the Proton Therapy Center at MD Anderson Cancer Center to view phantoms irradiated by 3.5 × 1010 protons with a kinetic energy of 75.8 MeV delivered in 101.5 ms-long spills yielding a dose rate of 164 Gy s−1. Most in-spill events were due to prompt gammas. Reconstructed post-spill tomographic events, recorded for up to 20 min, yielded quantitative imaging and dosimetric information. These findings open a new and novel modality for imaging and monitoring of FLASH proton therapy exploiting in-spill prompt gamma imaging followed by post-spill PET imaging.

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KW - PET dosimetry

KW - PET imaging

KW - Proton therapy

KW - prompt gammas

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The first probe of a FLASH proton beam by PET

Abstract

Keywords

ASJC Scopus subject areas

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