The genetics of pancreatic adenocarcinoma: A roadmap for a mouse model

Nabeel Bardeesy; Norman E. Sharpless; Ronald A. DePinho; Glenn Merlino

doi:10.1006/scbi.2000.0371

The genetics of pancreatic adenocarcinoma: A roadmap for a mouse model

Nabeel Bardeesy, Norman E. Sharpless, Ronald A. DePinho, Glenn Merlino

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Pancreatic cancer is among the leading causes of cancer death. Although a genetic profile for pancreatic cancer is emerging, many biological aspects of this disease are poorly understood. Indeed, fundamental questions regarding progenitor cell lineages, host stromal milieu, and the role of specific genetic alterations in tumor progression remain unresolved. A mouse model engineered with signature mutations would provide a powerful ally in the study of pancreatic cancer biology and may guide improved prognostic assessment and treatment for the human disease. In this review, we discuss the molecular basis for normal pancreatic development and the genetics of human pancreatic adenocarcinoma in the hope of charting a course for the development of a faithful mouse model for this lethal cancer.

Original language	English (US)
Pages (from-to)	201-218
Number of pages	18
Journal	Seminars in cancer biology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1006/scbi.2000.0371
State	Published - 2001
Externally published	Yes

Keywords

Genetics
Pancreatic cancer
Transgenic mouse

ASJC Scopus subject areas

Cancer Research

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10.1006/scbi.2000.0371

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title = "The genetics of pancreatic adenocarcinoma: A roadmap for a mouse model",

abstract = "Pancreatic cancer is among the leading causes of cancer death. Although a genetic profile for pancreatic cancer is emerging, many biological aspects of this disease are poorly understood. Indeed, fundamental questions regarding progenitor cell lineages, host stromal milieu, and the role of specific genetic alterations in tumor progression remain unresolved. A mouse model engineered with signature mutations would provide a powerful ally in the study of pancreatic cancer biology and may guide improved prognostic assessment and treatment for the human disease. In this review, we discuss the molecular basis for normal pancreatic development and the genetics of human pancreatic adenocarcinoma in the hope of charting a course for the development of a faithful mouse model for this lethal cancer.",

keywords = "Genetics, Pancreatic cancer, Transgenic mouse",

author = "Nabeel Bardeesy and Sharpless, {Norman E.} and DePinho, {Ronald A.} and Glenn Merlino",

note = "Funding Information: The authors would like to thank Jonathan Glickman and Marcus Bosenberg for critical review of the manuscript. We are very grateful to Joe Depinho for the artwork in Figure 1 and Syed Ali for Figures 2 and 4. The photomicrographic images in Figure 3 are courtesy of Jonathan Glickman (Pathology Department, Brigham and Women{\textquoteright}s Hospital). NB is supported by the John Peter Hoffman Award from the American Cancer Society. NES is a Howard Hughes Medical Institute Physician Postdoctoral Fellow.",

year = "2001",

doi = "10.1006/scbi.2000.0371",

language = "English (US)",

volume = "11",

pages = "201--218",

journal = "Seminars in cancer biology",

issn = "1044-579X",

publisher = "Academic Press Inc.",

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T1 - The genetics of pancreatic adenocarcinoma

T2 - A roadmap for a mouse model

AU - Bardeesy, Nabeel

AU - Sharpless, Norman E.

AU - DePinho, Ronald A.

AU - Merlino, Glenn

N1 - Funding Information: The authors would like to thank Jonathan Glickman and Marcus Bosenberg for critical review of the manuscript. We are very grateful to Joe Depinho for the artwork in Figure 1 and Syed Ali for Figures 2 and 4. The photomicrographic images in Figure 3 are courtesy of Jonathan Glickman (Pathology Department, Brigham and Women’s Hospital). NB is supported by the John Peter Hoffman Award from the American Cancer Society. NES is a Howard Hughes Medical Institute Physician Postdoctoral Fellow.

PY - 2001

Y1 - 2001

N2 - Pancreatic cancer is among the leading causes of cancer death. Although a genetic profile for pancreatic cancer is emerging, many biological aspects of this disease are poorly understood. Indeed, fundamental questions regarding progenitor cell lineages, host stromal milieu, and the role of specific genetic alterations in tumor progression remain unresolved. A mouse model engineered with signature mutations would provide a powerful ally in the study of pancreatic cancer biology and may guide improved prognostic assessment and treatment for the human disease. In this review, we discuss the molecular basis for normal pancreatic development and the genetics of human pancreatic adenocarcinoma in the hope of charting a course for the development of a faithful mouse model for this lethal cancer.

AB - Pancreatic cancer is among the leading causes of cancer death. Although a genetic profile for pancreatic cancer is emerging, many biological aspects of this disease are poorly understood. Indeed, fundamental questions regarding progenitor cell lineages, host stromal milieu, and the role of specific genetic alterations in tumor progression remain unresolved. A mouse model engineered with signature mutations would provide a powerful ally in the study of pancreatic cancer biology and may guide improved prognostic assessment and treatment for the human disease. In this review, we discuss the molecular basis for normal pancreatic development and the genetics of human pancreatic adenocarcinoma in the hope of charting a course for the development of a faithful mouse model for this lethal cancer.

KW - Genetics

KW - Pancreatic cancer

KW - Transgenic mouse

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The genetics of pancreatic adenocarcinoma: A roadmap for a mouse model

Abstract

Keywords

ASJC Scopus subject areas

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